脂肪量与肥胖相关基因在肿瘤能量代谢中的作用

脂肪量与肥胖相关基因(FTO)是近年来发现的一种与肥胖相关的热门研究基因.多项研究证实FTO基因的改变与能量代谢密切相关；流行病学研究及荟萃分析也发现FTO基因的多态性与某些肿瘤(胰腺癌、子宫内膜癌、乳腺癌等)的发生风险有关.肿瘤细胞的能量代谢方式不同于正常细胞,研究FTO基因在肿瘤能量代谢中的功能调控已成为新的研究热点.

Roles of FTO gene in tumor metabolism

Fat mass and obesity associated gene (FTO) has been identified as a novel gene related with obesity in recent years. A large amount of studies report the significant association between FTO expression level and energy metabolism. Besides, epidemiological studies and meta-analysis studies indicate the possibility that FTO gene polymorphism is related with cancer risk such as pancreatic cancer, endometrial cancer, breast cancer and so on. Taken account of the special energy metabolism in cancer cells which is different from that in normal cells, it is rather a novel and hot hypothesis to be investigated that FTO plays an important role in regulating energy metabolism of cancers.