植物提取物抗肿瘤研究进展

 植物提取物是一类重要的抗肿瘤药物，抗肿瘤药物的研究主要集中于白藜芦醇、蓖麻毒素、表没食子儿茶素、冬凌草甲素、胡桃醌、槲皮素、苦参碱、去甲二氢愈创木酸等几种重要的植物提取物。体内外研究表明,植物提取物抗肿瘤的作用机制包括诱导凋亡、细胞毒性作用、诱导再分化、抗肿瘤血管形成和抗侵袭转移等，呈多环节多靶位，部分植物提取物已用于临床前研究。植物提取物抗肿瘤机制的深入研究对肿瘤治疗有重要意义，其完整机制有待进一步研究。

Plant extract anti-cancer research progress

Plant extracts are kinds of important anticancer drugs. Anticancer drugs research has focused on several important plant extracts such as resveratrol, ricin, epigallocatechin-3-gallate, oridonin, juglone,quercetin, matrine, nordihydroguaiaretic acid. In vitro and in vivo studies have shown that their anti tumor mechanisms including induction of apoptosis, cytotoxicity, induced redifferentiation, antiangiogesis, anti invasion and anti metastasis. Plant extracts have multi link and multi target. Part of them have been used in preclinical studies. In depth study of the anti tumor mechanisms of plant extracts on cancer treatment is important, and the full mechanism needs further study.