| 胡椒碱的致突变作用 |
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| 引用本文： | 陆景坤,陈朝军,王玉华,肖云峰,李文妍.胡椒碱的致突变作用[J].癌变．畸变．突变,2009,21(3):241-242. |
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| 作者姓名： | 陆景坤 陈朝军 王玉华 肖云峰 李文妍 |
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| 作者单位： | 内蒙古医学院药学院，内蒙古 呼和浩特 010059 |
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| 摘 要： | 背景与目的： 探讨胡椒碱的致突变性。 材料与方法： 用昆明种小鼠骨髓微核实验、小鼠次级精母细胞染色体畸变实验和精子畸变试验研究胡椒碱的致突变性。 结果： 胡椒碱574 mg/kg、287 mg/kg剂量组的小鼠骨髓微核率及小鼠次级精母细胞畸变率较阴性对照组显著增加(P均<0.01)；胡椒碱各剂量组精子畸变率较阴性对照组均显著增加(P均<0.01)。 结论： 在本实验条件下，胡椒碱有致突变的作用。
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| 关 键 词： | 胡椒碱 致突变性 |
| 收稿时间： | 2008-07-10 |
| 修稿时间： | 2008-09-09 |
The Mutagenicity of Piperine |
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| LU Jing-kun,CHEN Zhao-jun,WANG Yu-hua,XIAO Yun-feng,LI Wen-yan.The Mutagenicity of Piperine[J].Carcinogenesis,Teratogenesis and Mutagenesis,2009,21(3):241-242. |
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| Authors: | LU Jing-kun CHEN Zhao-jun WANG Yu-hua XIAO Yun-feng LI Wen-yan |
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| Institution: | Pharmacy Department, Inner Mongolia Medical College, Hohhot 010059, China |
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| Abstract: | BACKGROUND AND AIM: To study the potential mutagenicity of piperine.MATERIALS AND METHODS: Micronucleus assay,chromosomal aberration test and sperm toxicity assay of mice were studied.RESULTS: The ratios of micronucleus cells with piperine 574 mg/kg,287 mg/kg were increased compared with negative control.There were significant chromosomal damages with the piperine concentration of 574 mg/kg,287 mg/kg and notable sperm abnormalities with the piperine concentrations of 574 mg/kg,143 mg/kg compared with negati... |
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| Keywords: | pepper alkali mutagenicity |
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