重金属对秀丽线虫毒性排序的Meta回归分析

目的： 基于已发表的重金属对秀丽线虫毒性作用的文献，在排除其他影响因素的前提下，综合分析和比较重金属对秀丽线虫的毒性作用大小。方法：利用Scan It软件提取了20篇国内外相关文献中以图形表达的不同重金属对秀丽线虫不同指标的毒性数据，将相同指标进行汇总，以毒性指标终点为因变量，金属种类、浓度、暴露时间、发育期等为自变量，进行Meta回归模型分析。结果：各金属对秀丽线虫死亡率影响大小次序为：汞 (mercury，Hg)＞铜 (copper，Cu)＞铅 (lead，Pb)＞铬 (chromium，Cr)＞ 铝 (aluminum，Al)＞镉(cadmiun，Cd)＞钴(cobalt，Co)＞镍(nickel，Ni)＞锌(zinc，Zn)；对体长的影响大小次序为：Pb＞银 (silver，Ag) ＞Hg＞Co＞Al＞Cr＞Zn＞钙 (calcium，Ca)＞Ni；对世代时间的影响大小次序为：Ni＞Al＞Co＞Ag＞Cr＞Zn＞Cu＞Pb； 对头部摆动频率的影响大小次序为：Hg＞Pb＞Ni＞Ag＞Cu＞Zn＞Cr＞Co＞Cd＞Al。结论：Meta回归模型可用于分析不同重金属的研究，并对重金属毒性进行有效排序，但有些浓度下的毒性仍需要结合实验进行综合分析和验证。

Meta regression analysis of heavy metal toxicity on Caenorhabditis elegans

OBJECTIVE: Based on the published literature of heavy metal toxicity on Caenorhabditis elegans，and after controlling the effects of other factors，we analyzed and compared the toxicity of heavy metals on Caenorhabditis elegans. METHODS：We used Scan It software to extract data from 20 related literature which contained figures expressing different indices of toxicity of various heavy metals on Caenorhabditis elegans，we then built a Meta regression model using toxicity indices as the dependent variables，and different metals，concentration，exposure time，etc. as independent variables. RESULTS：The order of heavy metal on the mortality of Caenorhabditis elegans was：Mercury (Hg)＞Copper (Cu)＞Lead (Pb)＞Chromium (Cr)＞Aluminum (Al)＞Cadmiun (Cd)＞Cobalt (Co)＞Nickel (Ni)＞Zinc (Zn)；affecting body size was：Pb＞Silver (Ag)＞Hg＞Co＞Al＞ Cr＞Zn＞Calcium (Ca)＞Ni；the effect on general time was：Ni＞Al＞Co＞Ag＞Cr＞ Zn＞Cu＞Pb； with head thrashes was：Hg＞Pb＞Ni＞Ag＞Cu＞Zn＞Cr＞ Co＞Cd＞Al. CONCLUSION：Meta regression model could be used to integrate information on the toxicity of different heavy metals，and to sort them in order. However，more experimental data on sorting of toxicity is necessary to validate the toxicity of some metals.