理气复胃口服液对化疗后便秘的预防效果

目的 探讨理气复胃口服液对接受化疗的患者化疗后便秘的预防效果和安全性.方法 将100例化疗后符合纳入标准的肿瘤患者根据随机数字表分为治疗组和对照组,各50例,治疗组化疗第1天开始给予理气复胃口服液20 ml口服,3次/d,连续1周.对照组给予一般处理.采用NCI-CTC 3.0毒性分级标准比较两组化疗后便秘的发生率和程度、腹胀的程度和持续时间、厌食、腹泻情况.结果 治疗组、对照组化疗后便秘的发生率分别为48％（24/50）和98％（49/50） （P＜ 0.000 1）,两组全部为1～3级便秘（P=0.036）;化疗后腹胀的发生率分别为36％（18/50）和70％（35/50） （P=0.0013）,腹胀的程度分级比较差异有统计学意义（P=0.033）,持续时间两组分别为（2.22±1.48）d和（3.43±1.60）d（P=0.01）.化疗后厌食的发生率分别为56％（28/50）和90％（45/50）（P＜ 0.000 1）,厌食程度比较差异无统计学意义（P=0.818）.治疗组1例患者出现轻度腹泻.结论 理气复胃口服液能有效预防化疗后便秘及腹胀,值得临床进一步扩大样本量研究和应用.

Prevention effect of Liqifuwei oral liquid for chemotherapy induced-constipation

Objective To evaluate the efficacy and safety of Liqifuwei oral liquid for prophylaxis of chemotherapy induced-constipation through a randomized controlled trial.Methods Cancer patients who met the inclusion criterias were randomly assigned to the treatment group and the control group by random number table.Liqifuwei oral liquid was prescribed 20 ml per tid from the first day of chemotherapy in the treatment group,the control group accepted the conventional treatment.Incidence and degree of chemotherapy inducedconstipation,degree and duration time of abdominal distension,anorexia and diarrhea were compared by criteria of NCI-CTC 3.0.Results A total of 100 patients were eligible,including 50 patients in the treatment group and 50 patients in the control group respectively.Incidence rate of chemotherapy induced-constipation was 48 ％ （24/50） and 98 ％ （49/50） （P ＜ 0.000 1）,all patients were grade 1-3 constipation,no grade 4 and grade 5 constipation （P =0.036）.Incidence rate of abdominal distension was 36 ％ （18/50） and 70 ％ （35/50）（P =0.001 3）,abdominal distension degree （P =0.033）,duration time of abdominal distension was （2.22±1.48）days and （3.43±1.60） days （P =0.01）.Incidence rate of anorexia was 56 ％ （28/50） and 90 ％ （45/50）（P ＜ 0.000 1）,there was no significance different of anorexia degree （P =0.818）.One patient in treatment group underwent mild diarrhea.Conclusion The prophylaxis of Liqifuwei oral liquid for chemotherapy induced-constipation and abdominal distension is effective,which deserves large-sample studies and clinic application.