重组RA538、反义c-myc腺病毒对不同细胞系转染效率与作用及其机制的研究 *

目的：研究放射免疫治疗（ＲＴＴ）对肿瘤转移的预防和治疗作用，寻找一种抑制肿瘤转移的方法。方法：采用＾１３１Ｉ－Ｃ５０治疗ＬＡ７９５肺腺癌小鼠模型。观察治疗前后小鼠的体重减轻量、瘤重、生存期、肺转移数。比较一、小鼠接种后不同时期给药分次小剂量ＲＴＴ与化疗、手术及对照组之间疗效差别。三、接种后不同时间截肢后综合治疗对荷瘤小鼠作用。结果：一、种后后第７人药，各治疗组与对照组比较，体重减轻少、瘤重轻、肺转

Multiple Low-Dose RIT with ~(131)I-C50 in Controlling and Preventing Metastasis in Tumor-Bearing Mice

Objective: To study the efficiency of radio-immuno-therapy (RIT) with 131I-C50 to precaution and treatment of tumor metastasis and develop a new metastasis suppression method.Methods: The effect was judged through body weight loss, tumor burden, life-span, and metastat- ic. Compared among the multiple low-dose RIT, chemotherapy, surgical resection and controls in different administration time after implantation of tumor and resection of tumor. Results: When the treatment was initiated at 7th day after implantation, the tumor suppression effects of treatment groups were significantly better than those of controls, with the best one in multiple low-dose RIT. Better results were achieved by starting treat- ment earlier. Surgical resection at 15th day after implantation, multiple low-dose RIT groups gained longer life-span and less metastatic nodules than others. Early operation improved therapeutic efficacy, especially in multiple low-dose RIT. Conclusion: Multiple low-dose RIT alone is bet- ter than chemotherapy and surgical treating. Early doing RIT is better than ther. One low-dose RIT Plus with operation had even better tumor suppression effect that RIT alone. Low-dose RIT co-operated with operation as early as possible can enhance the effects of treatment.