| 热休克对H22细胞膜HSP70蛋白及其mRNA水平的影响 |
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| 引用本文： | 吴伟忠,刘康达,汤钊猷,汤晓雷,吴厚生,胡新美,谢倩,高艳琴.热休克对H22细胞膜HSP70蛋白及其mRNA水平的影响[J].中国肿瘤生物治疗杂志,1998,5(1):5-8. |
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| 作者姓名： | 吴伟忠 刘康达 汤钊猷 汤晓雷 吴厚生 胡新美 谢倩 高艳琴 |
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| 作者单位： | 同济医科大学实验医学研究中心医学分子生物学研究室!武汉430030 |
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| 基金项目： | 卫生部科学研究基金(96-1-160)资助 |
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| 摘 要： | 将IL-2或/和IFN-γ基因体内转染腹腔巨噬细胞(MΦ),其表达的基因产物能提高MΦ的细胞毒活性,并诱导MΦ分泌TNF、IL-1和NO等抗肿瘤免疫介质.激发机体的非特异性免疫功能而产生抗肿瘤效应,特别是IL-2和IFN-γ基因联合转染MΦ,其表达的基因产物既能使MΦ产生更强的细胞毒活性并分泌高水平的TNF、IL-1和NO,又能激活脾CTL细胞,从而激发机体的非特异性和特异性免疫功能,产生更强的快同抗肿瘤效应.结果表明,IL-2和IFN-γ基因转染MΦ较单基因转染具有更强的抗瘤效应
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| 关 键 词： | 基因转染 腹腔巨噬细胞 抗肿瘤作用 IL-2基因 IFN-γ基因 |
| 收稿时间： | 1997/8/18 0:00:00 |
| 修稿时间： | 1997/11/21 0:00:00 |
Influence of Heat Shock Treatment upon the Expression of Membrane HSP70 and Its mRNA of H22 Cell |
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| Wu Weizhong,Liu Kangd,Tang Zhaoyou,Tang Xiaolei,Wu Housheng,Hu Xinmei,Xie Qian and Gao Yanqin.Influence of Heat Shock Treatment upon the Expression of Membrane HSP70 and Its mRNA of H22 Cell[J].Chinese Journal of Cancer Biotherapy,1998,5(1):5-8. |
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| Authors: | Wu Weizhong Liu Kangd Tang Zhaoyou Tang Xiaolei Wu Housheng Hu Xinmei Xie Qian and Gao Yanqin |
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| Institution: | Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032;Liver Cancer Institute , Zhongshan Hospital, Shanghai Medical University, Shanghai 200032 |
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| Abstract: | |
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| Keywords: | gene transfection peritoneal macmphage antitumor effect IL-2 gene IFN-y gene |
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