急性白血病长期生存相关因素研究

 目的　分析影响急性白血病（AL）长期生存的因素。方法　对143例中27例长期生存5年以上AL患者的临床资料进行回顾分析，AL患者诱导缓解期采用强烈联合化疗，并实行个体化用药原则，坚持缓解后正规的巩固强化治疗，长期随访观察，根据情况调整用药方案。结果　AL 143例中达到完全缓解112例（78.3 %），27例（18.9 %）达5年以上长期生存。结论　影响AL长期生存的主要因素为AL类型、白血病细胞负荷、髓外白血病、个体化治疗、达到完全缓解的时间、强化治疗的时间、规范的缓解后治疗等。

Study on factors associated with long-term survival of acute leukemia

Objective To analyze factors associated with long-term survival of acute leukemia(AL). Methods Clinical data is analyzed in 27 leukemia cases who had at least 5 years free survival (EFS). Combined intensive chemotherapy was administered under the principle of individualization to induce remission.Regular consolidation treatment after remission was strictly continued.Long-term follow up Was kept on,with the therapeutic regimen modified accordingly.Results Complete remission(CR) was achieved in 112 of 143(78.3%)AL patients and 27(18.9%)of them had survived more than 5 years.Conclusion The long-term survival of AL patients is related to the type of AL,leukemia cell burden,extramedullary leukemia, individual treatment,time required to achieve CR,continuous intensive chemotherapy and the regular postremission treatment.