氟比洛芬酯在甲状腺癌根治术中超前镇痛的疗效观察

目的：观察氟比洛芬酯在甲状腺癌根治术中超前镇痛的有效性。方法：40例患者随机分成A、B两组,每组20例,均采用气管内插管全身麻醉。A组为试验组,在气管插管完成后,手术开始前静脉推注氟比洛芬酯100mg,B组为对照组于手术结束时静脉推注氟比洛芬酯100 mg。两组均未使用术后自控镇痛。分别于手术后0.5h、4h、8h、12h以及24h采用视觉模拟评分法（VAS）进行疼痛评分,并观察有关不良反应。结果：A组在术后24h的疼痛评分明显低于B组（P〈0.05）。两组不良反应的发生率无显著差异。结论：氟比洛芬酯于甲状腺癌根治术术前使用能有效减轻术后疼痛。

Clinical effects of flurbiprofen axetil on preemptive analgesia during radical operation of thyroid cancer

Objective：To observe the preemptive analgesia effect of flurbiprofen axetil during radical operation of thyroid cancer.Methods： Fourty patients undergoing radical operation of thyroid cancer were randomly divided into two groups.Patients in both groups received general analgesia.After tracheal intubation,the patients in group A（n=20） received intravenous of flurbiprofen axetil 100mg before surgery,and those in group B（n=20） received intravenous of flurbiprofen axetil 100mg after suturing the incision.Patients controlled analgesia（PCA） was not used in two groups.Postoperative analgesia efficacy was assessed by Visual Analogue Scales（VAS） at 0.5h,4h,8h,12h and 24 h after extubation,and adverse reaction of flurbiprofen axetil were also observed.Results： VAS were significantly higher in group B during 24h after surgery compared with those in group A（P0.05）.The adverse reactions were similar between two groups.Conclusion： Preemptive analgesia of flurbiprofen axetil can effectively alleviate the pain in radical operation of thyroid cancer.