| 替莫唑胺联合放疗治疗非小细胞肺癌脑转移的疗效观察 |
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| 引用本文： | 邬德东,杨芬,姚定珠.替莫唑胺联合放疗治疗非小细胞肺癌脑转移的疗效观察[J].陕西肿瘤医学,2013(9):1997-1999. |
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| 作者姓名： | 邬德东 杨芬 姚定珠 |
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| 作者单位： | [1]宝鸡市中心医院肿瘤内科,陕西宝鸡721008 [2]宝鸡市中心医院消化内科,陕西宝鸡721008 [3]宝鸡市中心医院神经外科,陕西宝鸡721008 |
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| 摘 要： | 目的：观察替莫唑胺联合全脑照射治疗非小细胞肺癌脑转移的疗效.方法：收集非小细胞肺癌脑转移患者40例,随机分成2组,A组接受6MV-X全脑照射DT 40Gy/20f,常规分割DT 2Gy/f;B组接受6MV-X全脑照射DT 40Gy/20f,常规分割DT 2Gy/f,同时口服替莫唑胺胶囊行同步化疗.结果：A、B两组近期疗效（CR＋ PR）及复发中位时间有显著性差异.结论：同步放化疗能提高非小细胞肺癌脑转移患者的疗效,并延长复发中位时间.
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| 关 键 词： | 替莫唑胺 同步放化疗 非小细胞肺癌 脑转移 |
Whole brain radiotherapy combined with temozolomide in the treatment of non-small cell lung cancer with brain metastasis |
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| Wu Dedong.Whole brain radiotherapy combined with temozolomide in the treatment of non-small cell lung cancer with brain metastasis[J].Shaanxi Oncology Medicine,2013(9):1997-1999. |
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| Authors: | Wu Dedong |
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| Institution: | Wu Dedong(Department Of Medical Oncology, Baoji Minicipal Central Hospital,Shaanxi Baoji 721008, China) Yang Fen(Department Of Gastroenterology, Baoji Minicipal Central Hospital,Shaanxi Baoji 721008, China) Yao Dingzhu(Department Of Neurosurgery, Baoji Minicipal Central Hospital,Shaanxi Baoji 721008, China) |
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| Abstract: | Objective：To investigate the efficacy of temozolomide with concomitant whole brain radiotherapy for non-small cell lung cancer with brain metastasis.Methods：All 40 cases of non-small cell lung cancer with brain metastasis were divided into 2 groups（group A and group B） randomly.The patients in group A received whole brain radiotherapy,patients in the group B received whole brain radiotherapy with concomtant temozolomide.Results：The efficient and median relapse time had significant differences between 2 groups.Conclusion：Temozolomide with concomtant whole brain radiotherapy can improve the efficacy of non-small cell lung cancer with brain metastasis. |
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| Keywords: | temozolomide chemoradiation non-small cell lung cancer brain metastasis |
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