| 胃肠间质瘤复发危险度的临床分析 |
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| 引用本文： | 郑春辉,朱延收,王国富,高洪宇,薛英威,王宽.胃肠间质瘤复发危险度的临床分析[J].肿瘤,2011,31(6):549-552. |
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| 作者姓名： | 郑春辉 朱延收 王国富 高洪宇 薛英威 王宽 |
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| 作者单位： | 哈尔滨医科大学第三临床医学院胃肠外科,哈尔滨,150086 |
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| 摘 要： | 目的:探讨不同临床病理因素对胃肠间质瘤(gastrointestinal stromal tumor,GIST)预后的影响,以期为GIST诊断和治疗以及预后判断提供依据。方法:回顾性分析2001年1月—2006年12月接受手术治疗的128例GIST患者的临床病理资料并进行随访,分析肿瘤原发部位、肿瘤大小、组织学类型、核分裂相、远处转移、甲磺酸伊马替尼等因素和GIST危险度与生存率之间的关系。结果:本组患者CD117表达阳性率为94.5%(121/128),CD34表达阳性率为72.7%(93/128)。按照Miettinen危险度分级标准,相同危险度的胃间质瘤与非胃间质瘤的生存率差异无统计学意义;而组织学类型与危险度分级相关(P=0.0282)。远处转移与GIST患者的生存率密切相关(P<0.0001)。甲磺酸伊马替尼治疗GIST可以明显提高中-高危险度GIST患者的生存率。结论:Miettinen危险度分级标准作为GIST的预后判定标准更为合理。组织学类型和远处转移可以作为评估GIST的重要因素,应在分级标准中予以体现。对中-高度危险的GIST患者,应建议口服甲磺酸伊马替尼治疗。
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| 关 键 词： | 胃肠间质瘤 危险因素 预后 |
Assessment of recurrence risk in gastrointestinal stromal tumors |
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| ZHENG Chun-hui,ZHU Yan-shou,WANG Guo-fu,GAO Hong-yu,XUE Ying-wei,WANG Kuan.Assessment of recurrence risk in gastrointestinal stromal tumors[J].Tumor,2011,31(6):549-552. |
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| Authors: | ZHENG Chun-hui ZHU Yan-shou WANG Guo-fu GAO Hong-yu XUE Ying-wei WANG Kuan |
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| Institution: | ZHENG Chun-hui,ZHU Yan-shou,WANG Guo-fu,GAO Hong-yu,XUE Ying-wei,WANG Kuan Department of Gastrointestinal Surgery,School of Third Clinical Medicine,Harbin Medical University,Harbin 150086,China |
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| Abstract: | Objective:To investigate the relationship between the clinicopathological factors and the prognosis of patients with gastrointestinal stromal tumor(GIST),and to provide clinical evidence supporting appropriate diagnosis,treatment and prognosis determination.Methods:The medical records of 128 patients with GIST undergoing surgical resection between Jan 2001 and Dec 2006 were analyzed retrospectively.All patients received follow-up care.The associations of primary tumor location,tumor size,histology,mitotic c... |
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| Keywords: | Gastrointestinal stromal tumors Risk factors Prognosis |
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