| p21激活激酶在肿瘤中的作用及其靶向治疗 |
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| 引用本文： | 陆雯,万小平.p21激活激酶在肿瘤中的作用及其靶向治疗[J].肿瘤,2012,32(8):654-658. |
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| 作者姓名： | 陆雯 万小平 |
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| 作者单位： | 上海交通大学医学院附属国际和平妇幼保健院妇产科,上海,200030 |
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| 基金项目： | 国家自然科学基金资助项目(编号:81072139;81172476) |
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| 摘 要： | p21激活激酶(p21-activated kinases,Paks)是一类丝氨酸/苏氨酸激酶,在进化上高度保守.Paks可被多种上游信号特别是小G蛋白Rho家族的Rac和Cdc42激活,对多种重要的信号通路及细胞功能进行调控.Paks在多种肿瘤中异常表达,参与细胞骨架重构、细胞运动、细胞增殖、分化、凋亡、有丝分裂及血管生成等,在肿瘤的发生、发展中起重要作用.因此,开展Paks靶向治疗的研究,可为肿瘤治疗提供新的思路.
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| 关 键 词： | 肿瘤 治疗 细胞生理学 p21激活激酶 |
The role of p21-activated kinases in cancer and targeted therapy |
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| LU Wen
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WAN Xiao-ping.The role of p21-activated kinases in cancer and targeted therapy[J].Tumor,2012,32(8):654-658. |
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| Authors: | LU Wen WAN Xiao-ping |
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| Institution: | Department of Obstetrics and Gynecology, International Peace Maternity & Child Health Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China |
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| Abstract: | The Paks (p21-activated kinases) are members of a family of serine/threonine kinases which are highly conserved throughout evolution in a variety of organisms. Paks can be activated by a variety of upstream signaling molecules, especially by Rac and Cdc42 from Rho family small G proteins. The activated Paks play an important role in regulating many signaling pathways and cell function. The aberrant expression of Paks has been observed in a variety of cancers. Paks promote tumorigenesis through regulating cytoskeleton remodeling, cell motility, cell proliferation, cell differentiation, apoptosis, mitosis and angiogenesis. It appears promising to consider Paks as potential therapeutic targets in cancer therapy. |
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| Keywords: | Neoplasms Therapy Cell physiology p21-activated kinases |
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