| 肝癌共病抑郁分子机制的研究进展 |
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| 引用本文： | 唐如冰,王琪,游雪梅.肝癌共病抑郁分子机制的研究进展[J].实用肿瘤学杂志,2022,36(3):239-244. |
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| 作者姓名： | 唐如冰 王琪 游雪梅 |
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| 作者单位： | 1.广西医科大学附属肿瘤医院肝胆外科(南宁 530021);2.广西医科大学附属肿瘤医院实验研究部;3.区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学) |
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| 基金项目： | 国家自然科学基金项目(编号:81960308) |
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| 摘 要： | 肝癌患者共病抑郁的发生率极高,且抑郁是影响肝癌患者预后的不良因素。了解肝癌共病抑郁的分子机制对疾病的诊断和治疗至关重要。因此,本文以两者涉及的发病机制为出发点,结合现有的研究成果,从自主神经功能紊乱、下丘脑-垂体-肾上腺(Hypothalamic-pituitary-adrenal,HPA)轴功能异常、炎症因子比例失调、5-羟色胺(5-hydroxytryptamine,5-HT)系统调节异常、肠道菌群失调和氧化应激反应六个方面就两者共病的分子机制研究进展做一综述。
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| 关 键 词： | 肝癌 抑郁 共病 分子机制 |
| 收稿时间： | 2021-08-25 |
Research progress in molecular mechanism of liver cancer comorbid and depression |
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| TANG Rubing,WANG Qi,YOU Xuemei.Research progress in molecular mechanism of liver cancer comorbid and depression[J].Journal of Practical Oncology,2022,36(3):239-244. |
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| Authors: | TANG Rubing WANG Qi YOU Xuemei |
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| Institution: | 1. Department of Hepatobiliary Surgery,The Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China;2. Department of Experimental Research,The Affiliated Tumor Hospital of Guangxi Medical University;3.Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education |
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| Abstract: | The incidence of comorbid depression in patients with liver cancer is extremely high.The depression is an adverse factor affecting the prognosis of liver cancer patients.Understanding the molecular mechanism of liver cancer comorbid and depression is crucial for the diagnosis and treatment of the disease.Therefore,this paper reviews the pathogenesis involved in both as a starting point and combines the existing research results from autonomic dysfunction,hypothalamic-pituitary-adrenal(HPA)axis dysfunction,inflammatory cytokines imbalance,abnormal regulation of 5-hydroxytryptamine(5-HT)system,imbalance of intestinal flora,and oxidative stress are reviewed. |
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| Keywords: | Liver cancer Depression Comorbidities Molecular mechanism |
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