50例新疆维吾尔族食管鳞癌组织中survivin、p53蛋白的表达及临床意义

目的:探讨survivin、p53蛋白在维吾尔族食管鳞癌组织中的表达及其与临床病理指标的相关性,并进一步探讨其在食管鳞癌发生、发展中的作用.方法:应用免疫组织化学法(EnVision二步法),检测survivin和p53蛋白在50例食管鳞癌组织及18例食管正常切缘组织中的表达情况.结果:50例食管鳞癌中survivin和p53基因的阳性表达率为66％和38％,明显高于对照组(食管正常切缘组织)(P＜0.05).survivin、p53蛋白在中晚期食管癌中的阳性表达与食管癌的分期、分化程度相关(P＜0.05),而与食管鳞癌患者的年龄、性别、肿瘤大小、浸润深度、有无淋巴结转移无关(P＞0.05).survivin与p53蛋白在食管鳞癌中的表达无显著相关(r =0.040,P＞0.05).结论:survivin、p53蛋白在食管鳞癌组织中的表达明显高于食管正常组织.表达的高低与食管鳞癌临床分期、病理分化程度有关,有助于判断食管鳞癌的恶性程度及临床预后.

Expression and clinicopathological significance of survivin , p53 protein in esophageal squamous cell carcinoma of Xinjiang uygur nation

Objective:To investigate the expression of survivin,p53 protein and its correlation with clinicopathological features in the uygur patients.Methods: The expression of survivin and p53 protein 50 cases of esophageal squamous cell carcinoma tissues and 18 cases of adjacent tissues was assessed by SP immunohistochemical method.Results: The positive rates of survivin and p53 in the cancer tissues were 66% and 38%,significantly higher than those in the control group(adjacent tissues)(P<0.05);The positive rate of survivin and p53 was closely correlated with TNM stage and degree of tumor differentiation(P<0.05),but showed no statistical associated with age,sex,tumor size,infiltration depth and lymph node metastasis(P>0.05).The expression of survivin had a negative correlation with that of p53(r=0.040,P>0.05).Conclusion: Survivin and p53 have high expression in ESCC tissues,and the positive rate was closely correlated with TNM stage and degree of tumor differentiation,They may play an important role in ESCC malignancy and the prognosis of patients.