| 乳腺癌ER、PR、HER-2在原发灶及复发转移灶中表达变化 |
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| 引用本文： | 邓智平,朱江,马宁强,宋张骏,汪存涛,王雁,李逢生,韩丕华,王虎霞.乳腺癌ER、PR、HER-2在原发灶及复发转移灶中表达变化[J].现代肿瘤医学,2011,19(8):1562-1564. |
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| 作者姓名： | 邓智平 朱江 马宁强 宋张骏 汪存涛 王雁 李逢生 韩丕华 王虎霞 |
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| 作者单位： | 1. 陕西省肿瘤医院乳腺科,陕西,西安,710061
2. 第四军医大学唐都医院肿瘤内科,陕西,西安,710038 |
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| 基金项目： | 陕西省卫生厅科学研究基金项目 |
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| 摘 要： | 目的:探讨ER、PR及Her-2在乳腺癌原发和复发转移灶中的表达变化及其相关性。方法:免疫组化法检测45例乳腺癌原发及复发转移灶中的ER、PR及HER-2表达。结果:ER在原发灶和复发转移灶之间的变化率为66.67%(30/45),PR总的变化率为17.78%,cerbB2癌基因蛋白总的变化率13.33%。结论:ER在乳腺癌原发灶和复发转移灶之间的表达的差异具有统计学意义(P<0.05)。PR及cerbB2癌基因蛋白的表达在原发灶和复发转移灶之间差异无显著性(P>0.05)。
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| 关 键 词： | 乳腺癌 复发转移灶 激素受体 cerbB2癌基因蛋白 免疫组织化学 |
Discordance of the Expression of ER,PR and Her-2 receptor statuses between primary breast cancer and recurrent focuses |
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| DENG Zhiping,ZHU Jiang,MA Ningqiang,SONG Zhangjun,WANG Cuntao,WANG Yan,LI Fengsheng,HAN Pihua,WANG Huxia.Discordance of the Expression of ER,PR and Her-2 receptor statuses between primary breast cancer and recurrent focuses[J].Journal of Modern Oncology,2011,19(8):1562-1564. |
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| Authors: | DENG Zhiping ZHU Jiang MA Ningqiang SONG Zhangjun WANG Cuntao WANG Yan LI Fengsheng HAN Pihua WANG Huxia |
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| Institution: | DENG Zhiping1,ZHU Jiang1,MA Ningqiang2,SONG Zhangjun1,WANG Cuntao1,WANG Yan1,LI Fengsheng1,HAN Pihua1,WANG Huxia1 1Shaanxi Province Tumor Hospital,Xi'an,710061,China,2Tangdu Hospital,Fourth Military Medical University,710038 |
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| Abstract: | Objective:To investigate discordance of ER,PR,and HER-2 status between primary and recurrence focuses of breast cancer.Methods: Immunohistochemistry assay was used to detect expression of ER,PR,and HER-2 in primary and recurrence focuses of 45 cases of breast cancer.Results: Total discordance rates of ER,PR and HR-2 were 66.67%,17.78%,13.33%,respectively.Conclusion: Positive rate of ER in primary focuses was 73.33%(30/45),significantly higher than that in metastatic focuses(40%,18/45)(P<0.05);while positive... |
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| Keywords: | breast cancer recurrence focuses hormone receptor HER-2 receptor immunohistochemistry assay |
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