青年乳腺癌临床病理特征及分子分型分析

目的：探讨青年乳腺癌临床病理特征及分子分型情况。方法：收集陕西省肿瘤医院2012年1月至2015年6月经手术切除、病理证实的年龄≤35岁的青年乳腺浸润性导管癌病例64例，随机抽取同期年龄＞35岁的中老年乳腺浸润性导管癌66例作为对照，回顾性分析其临床病理特征及分子分型情况。结果：青年乳腺癌与中老年乳腺癌在肿瘤大小、病理分期、淋巴结转移及 Ki －67表达方面差异有统计学意义（P ＜0．05），二者分子分型的分布差异无统计学意义（P ＞0．05）。结论：青年乳腺癌肿瘤体积大，病理分期晚，Ki －67表达指数高，应重视其早期筛查与治疗，其高侵袭转移机制有待进一步研究。

Clinico -pathologic characteristics and molecular phenotypes of breast cancer in young patients

Objective:To investigate the clinico -pathologic characteristics and molecular phenotypes of breast cancer in young patients.Methods:Data from 64 cases of infiltrating ductal carcinoma in young patients(age≤35 years)who underwent surgery between January 2012 and June 2015 were reviewed.66 cases of infiltrating ductal car-cinoma in middle -aged and elderly patients(age >35 years)during the corresponding period were randomly selected as controls.The clinico -pathologic characteristics and molecular phenotypes were retrospectively analyzed.Results:The young patients of breast cancer significantly different from the middle -aged and elderly patients in terms of tumor size,pathologic stage,lymph node metastasis and the expression of Ki -67(P <0.05).There were no signifi-cant differences of the molecular phenotypes between them(P >0.05).Conclusion:Young patients of breast cancer have larger size,more lated pathologic stage and higher expression of Ki -67 compared with the middle -aged and elderly.Early screening and prompt treatment are necessary for young patients of breast cancer.The mechanisms of the strong invasion and metastasis still need further study.