中医药治疗肺癌VATS术后咳嗽的一项单臂临床研究

目的:中医药治疗肺癌术后咳嗽的临床疗效评价及用药规律分析。方法:收集2020年7月20日至2021年2月3日在我院就诊的肺癌术后1周内的患者32例，通过莱塞斯特咳嗽量表（Mandarin Chinese version of the Leicester cough quality of life questionnaire,LCQ-MC）调查及外周血采集，评价中药治疗肺癌术后咳嗽疗效，分析用药规律。结果:32例患者治疗后CRP、IL-6显著低于治疗前（P＜0.05），其中22例术后咳嗽患者治疗后LCQ-MC总分、生理和心理领域评分高于治疗前（P＜0.05），最后通过聚类分析将35种高频药物聚成6类。结论:肺癌术后患者咳嗽的发生及转归与CRP密切相关，中药干预对咳嗽的改善具有积极作用，治疗用药上要兼顾肺脾，标本同治。

A single arm clinical study of traditional Chinese medicine in the treatment of cough after VATS for lung cancer

Objective:To evaluate the clinical efficacy and analyze the medication law of traditional Chinese medicine in the treatment of postoperative cough of lung cancer.Methods:32 patients with lung cancer within 1 week after operation treated in our hospital from July 20,2020 to February 3,2021 were collected.The efficacy of traditional Chinese medicine in the treatment of postoperative cough of lung cancer was evaluated through Mandarin Chinese version of the Leicester cough quality of life questionnaire (LCQ-MC) and peripheral blood collection.Also,the law of medication was analysed.Results:CRP and IL-6 in 32 patients after treatment were significantly lower than those before treatment (P＜0.05),and the total score of LCQ-MC,physical and psychological fields in 22 patients with postoperative cough after treatment were higher than those before treatment（P＜0.05）.Finally,35 kinds of high-frequency drugs were clustered into 6 categories by cluster analysis.Conclusion:The occurrence and prognosis of cough in postoperative patients with lung cancer are closely related to CRP.Traditional Chinese medicine intervention has a positive effect on the improvement of cough.In treatment,both lung and spleen should be taken into account and the symptoms should be treated together.