癌症相关成纤维细胞诱导的上皮间质转化增强肿瘤细胞干性的研究进展

在肿瘤细胞干性的获得和维持方面，肿瘤微环境扮演着十分重要的角色。作为其中数量最多的基质细胞，癌症相关成纤维细胞(cancer-associated fibroblasts,CAFs)可通过旁分泌信号和改变基质硬度的方式，诱导邻近的肿瘤细胞发生上皮-间质转化(epithelial-mesenchymal transition,EMT)，使上皮来源细胞部分或完全地获得间充质表型。当细胞处于EMT进程中的某个过渡阶段时，即可被诱导表达干细胞表型，促进肿瘤的发生与进展。本文主要回顾了CAFs、EMT和肿瘤细胞干性相互之间的关系以及相关分子机制的研究，并尝试论述CAFs诱导肿瘤细胞的EMT增强其细胞干性。

Enhancement of cancer cell stemness by cancer-associated fibroblasts via epithelial-mesenchymal transition

Tumor microenvironment plays an important role in the induction and maintenance of tumor cell stemness.Asthe most abundant stromal cells of tumor microenvironment,cancer-associated fibroblasts(CAFs) can induce epithelial-mesenchymal transition(EMT) of adjacent tumor cells through paracrine signals and regulation of matrix stiffness and thereby make epithelial-derived cells partially or completely gain mesenchymal phenotype.A transitional stage in the EMT program can induce stemness of tumor cells,and promote the initiation and progression of tumor.Here,we reviewed somerecent studies about the relationship between CAFs,EMT and cancer stemness and the related molecular mechanism,and try to connect them in the form of CAFs-EMT-stemness of tumor cells.