细胞因子在分化型甲状腺癌诊疗中的应用进展北大核心

甲状腺癌是内分泌系统常见的恶性肿瘤之一,其发病率呈逐年上升趋势。甲状腺癌以分化型甲状腺癌(differentiated thyroid carcinoma, DTC)为主,尽管多数DTC患者经规范化治疗后预后良好,但由于部分肿瘤的病理类型侵袭性较高或肿瘤组织分化程度较低,病情进展迅速导致患者总生存时间显著缩短。近年来,有关炎症与肿瘤之间相关性的研究越来越多,炎性微环境的改变在肿瘤发病机制中的作用逐渐被证实,更多的证据表明细胞因子可作为肿瘤的良恶性鉴别、预后判断提示及诊疗方案选择等的重要参考依据。本文就部分细胞因子在DTC诊疗中的应用进展进行论述,旨在为DTC的诊疗与预后判断等提供参考依据。

Progress in the application of cytokines in the diagnosis and treatment of differentiated thyroid carcinoma

Thyroid carcinoma is one of the most common endocrine malignant tumors, and its incidence rate is increasing with years.Differentiated thyroid carcinoma(DTC)is the main type of thyroid carcinoma.Although most DTC patients have good prognosis after standardized treatment, due to the high invasiveness of pathological types or the loss of histological differentiation, the disease progresses rapidly, resulting in a significant reduction in the life span of patients.In recent years, there are more and more studies on the relationship between inflammation and tumor, and the role of inflammatory microenvironment in the pathogenesis of tumor been gradually confirmed.More evidence show that cytokines can be used as an important reference for the differentiation between benign and malignant tumors, prediction of prognosis and preference of diagnosis and treatment.In this paper, the application of some cytokines in DTC is reviewed, aiming to provide reference for the diagnosis, treatment and prognosis of thyroid carcinoma.