胆汁中生物标志物检测对胆管癌诊断价值的研究进展

胆管癌是一种起源于胆管上皮细胞的恶性肿瘤，发病率逐年上升，预后不良。缺乏敏感、特异的早期诊断标志物和替代治疗是患者生存受限的主要原因。虽然血液中的生物标志物更常用于区分疾病和健康状况，但血液中大量混杂因素的干扰限制了其在胆管癌诊断中的应用。鉴于胆汁中富含与胆管上皮细胞代谢途径相关的代谢物，正在成为特别针对胆管癌的生物标志物的丰富来源。本文就胆汁作为胆管癌生物标志物的现状和胆汁的获取分析方法作一综述。

Research progress of the diagnostic value of detection of biomarkers in bile for cholangiocarcinoma

Cholangiocarcinoma is a malignant tumor originating from bile duct epithelial cells.The incidence is increasing year by year,and the prognosis is poor.The lack of sensitive and specific early diagnostic markers and replacement therapy is the main reason for the patient's limited survival.Although biomarkers in the blood are more commonly used to distinguish disease from health status,the interference of a large number of confounding factors in the blood limits its application in the diagnosis of cholangiocarcinoma.Given that bile is rich in metabolites related to the metabolic pathways of bile duct epithelial cells,it is becoming a rich source of biomarkers specifically targeting cholangiocarcinoma.This article reviews the current status of bile as a biomarker for cholangiocarcinoma and methods for obtaining and analyzing bile.