结直肠癌PRL-3蛋白表达与临床关系的Meta分析

目的:研究促肝再生磷酸酶蛋白（PRL-3）在结直肠癌患者癌组织中的表达与临床病理特征的相关性。方法:检索知网、万方、和pubmed、Web of science、EMBASE等数据库以“PRL-3,结直肠癌”为主要检索词收集从2000年至2017年1月1日，国内外公开发表的关于PRL-3和结直肠癌临床病理特征关系的相关文献，对文献筛选和评价，符合标准的文献用RevMan5.3分析软件进行Meta分析。结果:最终纳入16篇文献，共包括1 489例病例，835例正常对照。PRL-3蛋白在结直肠癌组的表达与年龄、性别差异无统计学意义（P＞0.05）。PRL-3蛋白在正常大肠黏膜组织的表达低于结直肠癌组（I2=12%，P＜0.000 01，OR=4.01）；PRL-3蛋白在高分化的结直肠癌组的表达低于中、低分化组（OR=1.45，P=0.03，I2=39%）；PRL-3蛋白在未超过浆膜层组的表达低于侵及或超过浆膜层组（OR=2.36，P=0.01，I2=61%）；PRL-3蛋白在无淋巴结转移组的表达低于有转移组（OR=3.74,P＜0.000 01，I2=54%），采用随机效应模型进行Meta分析；PRL-3蛋白在不伴有肝转移组的表达低于有肝转移组（OR=2.88,P＜0.000 1，I2=36%）；PRL-3蛋白在Ⅰ+Ⅱ期组的表达低于Ⅲ+Ⅳ期组（OR=7.97,P＜0.000 01，I2=28%）。结论:PRL-3参与了结直肠癌发生、发展、转移过程，是预后不良的指征。

PRL-3 expression and its clinicopathological significance in colorectal cancer:Meta-analysis

Objective:To investigate the correlation of the expression phosphatase of regenerating liver-3 and clinicopathological features.Methods:Systematic computerized searches of CNKI,Wanfang,Cqvip,CBMdisc,PubMed,Web of science,EMBASE,Wiley Online Library databases meeting specified search criteria were peformed from year 2000 to Jan.1 2017,with "PRL-3,colorectal cancer"as key words,followed by a further screening according to inclusive and exclusive criteria,and the data meeting the selected standard were carried out by Revman5.3.Results:Sixteen reports were selected based on the standard,including 1 489 patients with colorectal cancer and 835 cases with normal controls.Expression of PRL-3 in colorectal cancer and age,gender,the difference was no significant（P＞0.05）.The level of PRL-3 in colorectal cancer higher in normal colonic mucosa （I2=12%，P＜0.000 01，OR=4.01）.The level of PRL-3 in moderately and poorly differentiated cancer were higher than well differentiation（OR=1.45，P=0.03，I2=39%）.The level of PRL-3 in colorectal cancer with the invased subserosa higher muscularis and serosal layer（OR=2.36，P=0.01，I2=61%）.The expression of PRL-3 in colorectal cancer with lymph node metastasis was higher than without metastasis （OR=3.74,P＜0.000 01，I2=54%）,so random effects model to merge was used.The expression of PRL-3 in Colorectal Cancer with liver metastasis was higher than without metastasis （OR=2.88,P＜0.000 1，I2=36%）.The level of PRL-3 in Ⅲ+Ⅳ of TNM stage was higher than ⅠandⅡstage （OR=7.97,P＜0.000 01，I2=28%）.Conclusion:PRL-3 expression in the incidence,development and metastasis of colorectal cancer is positively associated with the malignancy of the tumor and may be a sign of poor prognosis.