| 非典型急性早幼粒细胞白血病1例病案报道及文献复习 |
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| 引用本文： | 胡延平,关丽君,张继红,崔丽芬,张振忠,王韫秀,张男.非典型急性早幼粒细胞白血病1例病案报道及文献复习[J].现代肿瘤医学,2011,19(6):1200-1201. |
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| 作者姓名： | 胡延平 关丽君 张继红 崔丽芬 张振忠 王韫秀 张男 |
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| 作者单位： | 中国医科大学附属盛京医院,血液研究室,辽宁,沈阳,110022 |
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| 摘 要： | 目的:报道一例非典型急性早幼粒细胞白血病(APL),阐明Inv(11)(p15q22)相关非典型APL的临床遗传学特点,初步探究NUP98基因在白血病发病中的作用机制。方法:对该APL患者采用骨髓直接法和24小时培养法制备染色体,应用R显带技术进行核型分析。结果:R显带分析显示46,xy,inv(11)(p15q22)。结论:Inv(11)(p15q22)可导致非典型APL发病。
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| 关 键 词： | 白血病 染色体 NUP98 |
Atypical acute promyelocytic leukemia:a case report and review of literature |
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| HU Yan-ping,GUAN Li-jun,ZHANG Ji-hong,CUI Li-fen,ZHANG Zhen-zhong,WANG Wen-xiu,ZHANG Nan.Atypical acute promyelocytic leukemia:a case report and review of literature[J].Journal of Modern Oncology,2011,19(6):1200-1201. |
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| Authors: | HU Yan-ping GUAN Li-jun ZHANG Ji-hong CUI Li-fen ZHANG Zhen-zhong WANG Wen-xiu ZHANG Nan |
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| Institution: | Department of Hemotology/Oncology Laboratory,Shengjing Hospital of China Medical University,Shenyang 110022,China. |
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| Abstract: | Objective:To clarify the characterization of a chromosomal translocation involveing NUP98 at 11p15 in acute promyelocytic leukemia(APL),and to make a foundation for further research on the new partner gene of NUP98 and its function in leukemogenesis.Methods:Preparation was made using direct and 24 hours’culture of bone marrow cells.Karyotypic analysis was carried out by R-banding technique.Results:R-bandde analysis revealed a karyotype of 46,xy,inv(11)(p15q22).Conclusion:Inv(11)(p15q22) will probably lead to the pathogeny of atypical APL. |
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| Keywords: | NUP98 |
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