| 血清胱抑素C监测肺癌化疗早期肾损害价值分析 |
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| 引用本文： | 秦立东,孔繁宏.血清胱抑素C监测肺癌化疗早期肾损害价值分析[J].中华肿瘤防治杂志,2013,20(16):1267-1269. |
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| 作者姓名： | 秦立东 孔繁宏 |
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| 作者单位： | 山东省新汶矿业集团中心医院肿瘤科,山东泰安,271233 |
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| 摘 要： | 目的:通过测定肺癌患者化疗前后血清胱抑素C(Cystatin C,Cys C)的表达水平,探讨Cys C在预测早期肾损害的临床意义。方法:采用胶乳增强透射免疫比浊法测定96例肺癌患者化疗前后以及92名正常体检者血清Cys C水平,同时检测患者血清肌酐(scr)和24h尿肌酐(Ucr)水平,比较内生肌酐清除率(creatinine clearance,Ccr)。结果:96例肺癌患者化疗前、后(以第1个周期计算)Cys C水平分别为(1.20±0.37)和(1.78±0.56)mg/L;正常对照为(0.82±0.13)mg/L。肺癌患者化疗前后(1个周期)血清Cys C、Scr和Ccr水平差异均有统计学意义,P值分别为0.01、0.03和0.04;且化疗后血清Cys C的异常检出率(36.5%)显著高于Scr(15.6%)和Ccr(16.7%)的异常检出率,差异具有统计学意义,P=0.03。结论:Cys C是肺癌化疗患者早期肾损害的一项可靠、灵敏的指标。
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| 关 键 词： | 胱抑素C 化疗药物 肺癌 肾功能损害 |
Clinical significance of Serum cystatin C in monitoring early renal damage of lung cancer patients with chemotherapy |
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| QIN Li-dong,KONG Fan-hong.Clinical significance of Serum cystatin C in monitoring early renal damage of lung cancer patients with chemotherapy[J].Chinese Journal of Cancer Prevention and Treatment,2013,20(16):1267-1269. |
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| Authors: | QIN Li-dong KONG Fan-hong |
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| Institution: | Department of Oncology,Xinwen Mining Group Central Hospital,Tai’an 271233,P.R.China |
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| Abstract: | |
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| Keywords: | cystatin C chemotherapy lung cancer kidney function damage |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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