DICER基因多态性与食管癌淋巴结转移危险因素的关系

目的 探讨中国汉族人群中DICER基因rs3742330多态性与食管癌淋巴结转移危险因素的关系.方法 采用以医院为基础的病例-病例研究方法,采用基质辅助激光解析电离飞行时间质谱(MALDI-TOF MS)技术分析85例有淋巴结转移的食管癌和270例无淋巴结转移的食管癌DICER基因rs3742330基因多态性,计算各种基因型与食管癌淋巴结转移的发生风险及其95％可信区间.结果 dICER rs3742330 A＞G多态三种基因型AA、AG、GG在食管癌淋巴结转移组的频率分别为31.76％、61.18％、7.06％,在无淋巴结转移组的频率分别为34.44％、48.15％、17.41％,与携带DICERrs3742330 AA基因型的个体相比较,DICER rs3742330 GG基因型显著减少食管癌淋巴结转移发生的危险.结论 DICER rs3742330 A＞G基因多态性可能是食管癌淋巴结转移的保护性因素.

Association of Variant Allele of DICER and Decreased Risk of Esophageal Cancer Lymph Node Metastasis

Objective To investigate the relationship between DICER polymorphism and the susceptibility to lymph node metastasis in esophageal cancer in Chinese Han population.Methods Genotypes were determined by matrix-assisted laser desorption /ionization time-of-flight mass spectrometry(MALDI-TOF MS) method in 85 lymph node metastasis positive patients and 270 lymph node metastasis negative patients.Results The DICER rs3742330 A>G genotype frequencies were 31.76%(AA),61.18%(AG),7.06%(GG) in the lymph node positive group and 34.44%(AA),48.15%(AG),17.41%(GG) in the lymph node negative group,respectively.Logistic regression analyses revealed that the risk associated with DICER rs3742330 GG genotype was 0.36(95%CI=0.15~0.88) which was much lower than DICER rs3742330 AA+AG genotype.Conclusion DICER rs3742330 A>G polymorphism may be a protective factor of lymph node metastasis.