| 肿瘤细胞中HER2与脂肪酸合酶的关系 |
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| 引用本文： | 梁颖莉,熊威斌,李余发,余力.肿瘤细胞中HER2与脂肪酸合酶的关系[J].肿瘤防治研究,2015,42(6):614-617. |
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| 作者姓名： | 梁颖莉 熊威斌 李余发 余力 |
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| 作者单位： | 510280 广州，南方医科大学珠江医院病理科 |
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| 基金项目： | 国家青年自然科学基金（81201855）；广东高校优秀青年创新人才培养计划项目（2012LYM_0037） |
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| 摘 要： | 脂肪酸代谢和机体的能量平衡与肿瘤发生发展密切相关。脂肪酸合成酶（fatty acid synthase, FASN）作为一个代谢性癌基因，是能量链中的核心分子。近年来不少研究发现FASN和人表皮生长因子受体2（human epidermal growth factor receptor 2, HER2）之间存在双向分子联系，共同促进癌细胞转化、增殖、侵袭、转移、耐药等。本文对肿瘤细胞中二者相互作用作一综述。
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| 关 键 词： | 人表皮生长因子受体2 脂肪酸合酶 肿瘤细胞 信号通路 |
| 收稿时间： | 2014-09-19 |
Review on Relationship Between HER2 and Fatty Acid Synthase in Tumor Cells |
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| LIANG Yingli,XIONG Weibin,LI Yufa,YU Li.Review on Relationship Between HER2 and Fatty Acid Synthase in Tumor Cells[J].Cancer Research on Prevention and Treatment,2015,42(6):614-617. |
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| Authors: | LIANG Yingli XIONG Weibin LI Yufa YU Li |
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| Institution: | Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China |
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| Abstract: | Fatty acid metabolism and the body's energy balance are closely related to tumor development. Fatty acid synthase(FASN), as a metabolic oncogene, is the core of the energy chain molecules. In recent years, many studies have found that human epidermal growth factor receptor 2(HER2) establishes a bidirectional relationship with FASN, together to promote cancer cell transformation, proliferation, invasion, metastasis and drug resistance. This paper reviews on the relationship between FASN and HER2 in tumor cells. |
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| Keywords: | Human epidermal growth factor receptor 2(HER2) Fatty acid synthase(FASN) Tumor cells Signal pathway |
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