T1期食管鳞状细胞癌组织肿瘤出芽与内镜分型及恶性程度的关系

目的 探讨T1期食管鳞状细胞癌组织中肿瘤出芽的临床病理意义。方法 在T1期食管鳞状细胞癌（SCC）切除组织中查找肿瘤出芽，并分析肿瘤出芽与内镜分型和各种病理参数之间的相关性，以验证肿瘤出芽是否可作为衡量浅表浸润性食管癌侵袭性的一项有用指标。结果 经表皮生长因子受体（EGFR）标记后肿瘤出芽检出率有明显提高（P<0.05）。肿瘤出芽检出率在T1b期食管SCC患者显著高于T1a期者，差异有统计学意义（P<0.05）；有淋巴结转移的病例肿瘤出芽检出率显著高于无转移者，差异有统计学意义（P<0.05）；ⅡB期者肿瘤出芽检出率显著高于ⅠB期，差异有统计学意义（P<0.05）。结论 肿瘤出芽在T1期食管SCC中检出率较高；EGFR免疫组织化学标记可提高食管SCC中肿瘤出芽的检出率；当T1期食管SCC出现肿瘤出芽时提示其更具侵袭性。

Relation Between Tumor Budding and Endoscopic Classification,Degree of Malignancyin T1 Stage Esophageal Squamous Cell Carcinoma

Objective To investigate the clinical pathological significance of tumor budding in T1 stage esophageal squamous cell carcinoma. Methods Tumor budding was searched for in the resected tissues of T1 stage esophageal squamous cell carcinoma(ESCC), and the relation between tumor budding and endoscopic classification, degree of malignancy in T1 ESCC were analyzed. Results The detection rate of tumor budding was significantly improved after EGFR labeling(P<0.05). The detection rate of tumor budding in T1b ESCC was significantly higher than that of T1a SCC(P<0.05). The detection rate of tumor budding in the cases with lymph node metastasis was significantly higher than that without lymph node metastasis(P<0.05). The detection rate of tumor budding in stage ⅡB ESCC was significantly higher than those with stageⅠB(P<0.05). Conclusion The detection rate of tumor budding in T1 ESCC is relatively high. The detection rates of tumor budding is improved by EGFR immunohistochemistrical labeling. The occurrence of tumor budding in T1 ESCC indicates more tumor aggression.