单中心非转移性男性乳腺癌临床病理特征和生存分析

目的探讨非转移性男性乳腺癌手术患者的临床病理特征、治疗策略及生存情况。方法回顾性分析152例非转移性成年男性乳腺癌患者的人口学特征、临床诊治和生存情况。结果所有病例中位发病年龄为58岁。93.4%的患者以乳房肿块为首发症状,4例为原位癌,148例浸润性癌中浸润性导管癌占86.8%,雌激素受体阳性率为93.9%(139例),人表皮生长因子阳性率仅为7.4%(11例)。手术以全乳切除为主(n=149, 98.0%),保乳少见(n=3, 2.0%),19例前哨淋巴结(SLN)活检中,4例提示转移,行腋窝淋巴结清扫(ALND),15例SLN阴性中8例行常规ALND,7例免除ALND。中位随访时间42.7(2～179.5)月。5年OS和DFS分别为82.4%和69.9%。结论淋巴结状态(N)与非转移性男性乳腺癌的无病生存时间和总生存时间明显相关,是男性乳腺癌患者预后的重要影响因素。

Clinicopathological Characteristics and Outcomes of Male Patients with Resected Distant Metastasis-Free Breast Cancer in A Single Center

Objective To investigate the clinicopathological features,treatment strategies and outcomes of male patients with resected distant metastasis-free breast cancer.Methods We retrospectively analyzed clinicopathological characteristics,clinical diagnosis,treatments and outcomes of 152 adult male patients with resected distant metastasis-free breast cancer.Results The median age was 58 years.Among 152 patients,the initial symptom of 142 cases was palpable lump and 4 cases were ductal carcinoma in situ.Among 148 cases of invasive carcinoma,128 cases were invasive ductal carcinoma,139 cases were estrogen receptor-positive and 11 cases were human epidermal growth factor receptor 2-positive.A total of 149 cases received mastectomy and 3 cases received breast conservation.Sentinel lymph node biopsy was performed on 19 patients,4 cases were positive and 15 cases were negative,while 8 patients underwent axillary lymph node dissection.The median follow-up time was 42.7(2-179.5)months.The 5-year overall survival rate and disease-free survival rate were 82.4%and 69.9%,respectively.Conclusion Lymph node status(N)is significantly associated with the disease-free survival and overall survival of male patients with resected distant metastasis-free breast cancer and it’s an important prognostic factor.