基于二氧化硅纳米粒子的抗肿瘤药物递送系统研究进展CSCD

近年来癌症治疗受到广泛关注,二氧化硅纳米颗粒因其独特的理化性质在肿瘤诊疗领域展现巨大潜力。基于二氧化硅纳米粒子的药物输送系统可被动或主动靶向肿瘤组织,并通过刺激响应的方式实现药物在肿瘤部位的可控释放,有效提高抗肿瘤药物在肿瘤部位的浓度,提高治疗效率。同时,二氧化硅纳米粒子通过负载造影剂可实现生物成像功能,用于肿瘤组织定位及药物追踪,实现更高效的抗肿瘤治疗。本文介绍了二氧化硅纳米粒子的制备方式,并对二氧化硅纳米粒子在药物靶向递送系统及生物成像领域中的研究进展进行综述。

Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles

In recent years,more and more attention has been paid to the development of cancer diagnosis and treatment,including nanoparticles-based methods.Silica nanoparticles show great potential in the field of tumor diagnosis and treatment because of its unique physical and chemical properties.The drug delivery system based on SiO2 NPs can passively or actively target tumor tissues,and controllably release of cytotoxic drug at the tumor tissue by responding to different stimuli modes.It can effectively increase the concentration of anti-tumor drugs at the tumor site and improve treatment efficiency.In addition,SiO2 NPs can be used for tumor tissue localization and drug tracking by loading contrast agent to achieve the function of biological imaging.In this way,more efficient anti-tumor treatment can be achieved.In this paper,we introduced the preparation methods of SiO2 NPs and review the research progress of SiO2 NPs in targeted drug delivery system and biological imaging field.