| 卡铂联合化疗治疗老年非小细胞肺癌剂量探讨 |
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| 引用本文： | 殷铁军,刘菁菁,杨剑霞,胡长耀.卡铂联合化疗治疗老年非小细胞肺癌剂量探讨[J].肿瘤防治研究,2004,31(11):706-708. |
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| 作者姓名： | 殷铁军 刘菁菁 杨剑霞 胡长耀 |
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| 作者单位： | 1. 430030,武汉,华中科技大学同济医学院附属同济医院综合医疗科
2. 430030,武汉,华中科技大学同济医学院附属同济医院肿瘤科 |
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| 摘 要： | 目的探讨老年非小细胞肺癌患者联合化疗时卡铂按AUC=5mg/ml·min(AUC,areaundertheconcentrationtimecurve)的剂量是否适宜。方法33例老年晚期非小细胞肺癌患者采用Taxol+CBP、Gemzar+CBP、NVB+CBP方案化疗,卡铂用药剂量按AUC=5的水平给药。全部患者共完成73周期化疗。每周期化疗前后对患者的化疗毒副反应及生活质量变化进行评估。结果骨髓毒副反应常见且较重,中性粒细胞出现Ⅲ/Ⅳ级副反应为47.9%(35/73)、血小板出现Ⅲ/Ⅳ级副反应为28.8%(21/73)。其余毒副反应不重。生存质量评分(依据国内肿瘤患者生存质量评分标准)平均下降6.5分。结论老年非小细胞肺癌患者联合化疗时,卡铂按AUC=5的剂量水平用药毒副反应较重,且对生存质量有不利影响,可能与剂量偏大有关。
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| 关 键 词： | 老年患者 非小细胞肺癌 卡铂 曲线下面积 生存质量 |
| 文章编号： | 1000-8578(2004)11-0706-03 |
| 收稿时间： | 2004-2-17 |
| 修稿时间： | 2004-4-1 |
A Study on Dose Level of Carboplatin Combined Chemotherapy in Treatment of Elder Non-small Cell Lung Cancer |
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| YIN Tie jun,LIU Qing qing,YANG Jian xia,HU Chang yao.A Study on Dose Level of Carboplatin Combined Chemotherapy in Treatment of Elder Non-small Cell Lung Cancer[J].Cancer Research on Prevention and Treatment,2004,31(11):706-708. |
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| Authors: | YIN Tie jun LIU Qing qing YANG Jian xia HU Chang yao |
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| Institution: | YIN Tie jun,LIU Qing qing,YANG Jian xia,HU Chang yao 1.Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China,2.Department of Oncology |
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| Abstract: | Objective Preliminarily to determine whether it was appropriate for elder patients with non small cell lung cancer to be treated by carboplatin at AUC=5 mg/ml·min level during combined chemotherapy.Methods 33 cases of elder patients with non small cell lung cancer in advanced stage had received 73 cycles combination chemotherapy. Chemotherapy schemes included Taxol+CBP,Gemzar+CBP and NVB+CBP. The dose of carboplatin was at AUC=5 mg/ml·min level (AUC, area under the concentration time curve). Side effects an... |
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| Keywords: | Senile patient Non small cell lung cancer Carboplatin Area under the curve Quality of life |
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