| 术前乳酸脱氢酶/白蛋白比值联合AFP评估肝细胞癌患者预后的价值 |
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| 引用本文： | 周永婕,王正峰,严俊,王海平,徐雯,周文策. 术前乳酸脱氢酶/白蛋白比值联合AFP评估肝细胞癌患者预后的价值[J]. 肿瘤防治研究, 2022, 49(4): 347-351. DOI: 10.3971/j.issn.1000-8578.2022.21.0994 |
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| 作者姓名： | 周永婕 王正峰 严俊 王海平 徐雯 周文策 |
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| 作者单位： | 1. 730000 兰州，兰州大学第一临床医学院；2. 730000 兰州，兰州大学第一医院普外科 ；3. 730000 兰州，甘肃省生物治疗与再生医学重点实验室；4. 730000 兰州，兰州大学第一医院耳鼻咽喉头颈外科 |
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| 摘 要： | 目的 探讨术前乳酸脱氢酶/白蛋白比值(LAR)联合甲胎蛋白(AFP)评估肝细胞癌(HCC)患者预后的价值.方法 回顾性分析106例HCC患者的临床资料;采用Kaplan-Meier法绘制生存曲线;采用单因素分析影响LAR的可能变量,应用Cox风险回归模型评估术前LAR和AFP对HCC患者预后的临床价值.结果 高LAR组...
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| 关 键 词： | 肝细胞癌 乳酸脱氢酶 白蛋白 甲胎蛋白 预后 |
| 收稿时间： | 2021-09-03 |
Value of Preoperative Lactate Dehydrogenase-to-Albumin Ratio Combined with AFP in Evaluating Prognosis of Patients with Hepatocellular Carcinoma |
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| ZHOU Yongjie,WANG Zhengfeng,YAN Jun,WANG Haiping,XU Wen,ZHOU Wence. Value of Preoperative Lactate Dehydrogenase-to-Albumin Ratio Combined with AFP in Evaluating Prognosis of Patients with Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2022, 49(4): 347-351. DOI: 10.3971/j.issn.1000-8578.2022.21.0994 |
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| Authors: | ZHOU Yongjie WANG Zhengfeng YAN Jun WANG Haiping XU Wen ZHOU Wence |
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| Affiliation: | 1. The First School of Clinical Medical College of Lanzhou University, Lanzhou 730000, China; 2. Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China; 3. Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou 730000, China; 4. Department of Otolaryngology Head and Neck Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China |
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| Abstract: | Objective To explore the value of preoperative LAR combined with AFP in evaluating the prognosis of patients with HCC. Methods We retrospectively analyzed the clinical data of 106 patients with HCC. Kaplan-Meier method was used to draw the survival curve. Univariate analysis was used to analyze possible variables affecting LAR. Cox risk regression model was used to evaluate the clinical value of preoperative LAR and AFP on the prognosis of HCC patients. Results The DFS and OS of the high LAR group and the high AFP group were shorter than those of the low LAR group and the low AFP group (P<0.05). LAR≥4.58, AFP≥400μg/L and T3-T4 were independent risk factors affecting DFS and OS of HCC patients (P<0.05). Postoperative interventional surgery was an independent factor influencing OS prolongation (P<0.05). The DFS and OS were the shortest in the high LAR and high AFP group, and the DFS and OS were the longest in the low LAR and low AFP group (P<0.05). Conclusion Preoperative LAR and AFP are independent poor prognostic factors of HCC. Preoperative LAR combined with AFP has a certain value in judging the prognosis of HCC patients. |
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| Keywords: | Hepatocellular carcinoma Lactate dehydrogenase Albumin Alpha-fetoprotein Prognosis |
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