Multiple Myeloma in Hispanics: Incidence,Characteristics, Survival,Results of Discovery,and Validation Using Real-World and Connect MM Registry Data |
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Authors: | Gurbakhash Kaur Mateo Mejia Saldarriaga Nishi Shah Donna D Catamero Lihua Yue Nadia Ashai Niyati Goradia Joshua Heisler Zhengrui Xiao Natasha Ghalib Tonya Aaron Daniel Cole Rebecca Foreman Ioannis Mantzaris Olga Derman Lizamarie Bachier R Alejandro Sica Noah Kornblum Murali Janakiram |
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Institution: | 1. Department of Medical Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;2. Department of Internal Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY;3. John Theurer Cancer Center, Hackensack, NJ;4. Department of Internal Medicine, Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY;5. Celgene Corporation, Summit, NJ;6. Department of Pathology, Albert Einstein College of Medicine, Bronx, NY;7. Division of Hematology, Oncology and Transplantation (HOT), Department of Medicine, University of Minnesota, Minneapolis, MN;1. Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China;2. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China;1. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States;2. Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84108, United States;3. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States;4. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55902, United States;5. Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco, San Francisco, CA, 94143, United States;1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;2. Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY;1. Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA;2. Division of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Section of Pediatric Hematology and Oncology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA;4. Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;5. Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;7. Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |
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Abstract: | BackgroundMultiple myeloma (MM) in Hispanics has never been studied. We therefore sought to determine the clinical characteristics and overall survival in MM of Hispanics compared to non-Hispanic whites (NHW) and non-Hispanic blacks (NHB).Patients and MethodsA single-center analysis of 939 patients diagnosed with MM from 2000 to 2017 with a large representation of NHB (n = 489), Hispanics (n = 281), and NHW (n = 169) was conducted to evaluate outcomes and disease characteristics. We used the Connect MM Registry, a large US multicenter prospective observational study with newly diagnosed MM patients, as a validation cohort.ResultsHispanics had a higher incidence of MM compared to NHW. The median age at presentation was 5 years younger (median, 65 years) in Hispanics compared to NHW (median, 70 years), and patients were more likely to present with renal dysfunction (estimated glomerular filtration rate < 30 mL/min). Hispanics had a higher proportion of Revised International Staging System (R-ISS) stage I disease compared to NHW and NHB (P = .03), while there was no difference in cytogenetics between Hispanics and NHB/NHW. In the multivariate analysis, only high-risk disease and response to first-line therapy significantly affected survival.ConclusionIn this first and largest analysis of MM in Hispanics, we found that Hispanics present at a younger age, have a higher incidence of renal dysfunction, and have low R-ISS stage disease at presentation. With equal access to therapy, Hispanics have survival similar to NHW/NHB. |
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Keywords: | African Americans Healthcare disparities Hispanic Americans Incidence Multiple myeloma |
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