多种放射性肺损伤动物模型的建立和效应评价研究

放射性肺损伤是胸部肿瘤放疗后常见并发症,随着对放射性肺炎研究不断深入,如何为基础研究和药物干预寻求最佳的动物模型和效应评价已成为当前亟待解决的难题之一。通过检索近10年文献,对不同放射性肺损伤模型动物及放射部位的选择、照射剂量的确定、照射方法的比较和动物模型效应评价进行了对比研究,以期寻找建立放射性肺损伤动物模型的稳定方法和较为明确的效应机制,为防护和减缓放射性肺损伤的发生发展而进行的基础研究和药物研制提供可靠的方法。

Establishment and effect evaluation of a variety of radiation-induced lung injury animal models

Radiation-induced lung injury (RILI) is a common complication after radiotherapy for thoracic tumors. It is one of the most urgent problems to explore the optimal animal model and evaluate the effect for basic research and drug intervention along with the extensive studies of radiation pneumonia. By reviewing the literatures published in recent 10 years, the selection of irradiation site, determination of irradiation dosage, irradiation method and effect evaluation were statistically compared among different RILI animal models, aiming to explore a stable method of establishing the animal model with RILI and identify a definite effect mechanism. It provides a reliable approach for basic research and drug development to prevent and mitigate the incidence and development of RILI.