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PET-CT同机融合精度验证及在放疗靶区勾画中的应用
引用本文:王学涛,于金明,杨国仁,巩合义.PET-CT同机融合精度验证及在放疗靶区勾画中的应用[J].中华放射肿瘤学杂志,2005,14(3):204-207.
作者姓名:王学涛  于金明  杨国仁  巩合义
作者单位:1. 250117,济南,山东省肿瘤医院物理室
2. 250117,济南,山东省肿瘤医院放疗科
3. 250117,济南,山东省肿瘤医院PET-CT中心
摘    要:目的验证PET-CT同机融合的精度并实际应用于患者,为放疗的PET-CT定位及靶区勾画提供临床依据。方法用不同浓度的^18FDG灌注体模上的标志点和不同尺寸的圆柱体,PET和CT以层厚4mm扫描后的影像传输至eNTEGRA工作站和放疗计划系统(TPS)工作站,进行图像融合和三维重建,在PET和CT影像上测量标志点之问的距离和PET-CT的融合误差。用扣除一定比例像素值的方法测量圆柱体的PET影像体积和CT影像体积,并把两者进行比较,同样的方法应用于10例非小细胞肺癌患者的10个肿瘤体积测量。结果eNTEGRA和TPS工作站有良好的长度线性,但后者的图像融合误差明显大于前者。不同体积肿瘤、不同浓度^18FDG需采用不同的像素值扣除比例。圆柱体和10个肿瘤PET影像体积和CT影像体积有较好的一致性。结论PET—CT同机融合的精度完全符合放疗的临床要求,扣除一定比例像素值的方法可用于PET影像的肿瘤范围的勾画。

关 键 词:放疗靶区  精度  验证  PET-CT  ^18FDG  放疗计划系统  CT影像  不同浓度  图像融合  工作站  临床依据  CT定位  影像传输  三维重建  体积测量  肺癌患者  非小细胞  方法应用  临床要求  标志点  肿瘤  圆柱  像素  比例  TPS  一致性  误差
修稿时间:2004年2月9日

Accuracy verification of PET-CT image fusion and its utilization in target delineation of radiotherapy
WANG Xue-tao,YU Jin-ming,YANG Guo-ren,GONG He-yi.Accuracy verification of PET-CT image fusion and its utilization in target delineation of radiotherapy[J].Chinese Journal of Radiation Oncology,2005,14(3):204-207.
Authors:WANG Xue-tao  YU Jin-ming  YANG Guo-ren  GONG He-yi
Abstract:Objective Evaluate the accuracy o f co-registration of PET and C T (PET-CT) images on line with phantom, and utilize it on patients to provide c l inical evidence for target delineation in radiotherapy. Methods A phantom with m arkers and different volume cylinders was infused with various concentrations of 18FDG, and scanned at 4?mm by PET and CT respectively. Aft er having been transmi tted into GE eNTEGRA and treatment planning system (TPS) workstations, the image s were fused and reconstructed. The distance between the markers and the errors were monitored in PET and CT images respectively. The volume of cylinder in PET and CT images were measured and compared by certain pixel value proportion deduc tion method. The same procedure was performed on the pulmonary tumor image in te n patients. Results eNTEGRA and TPS workstations had a good length linearity, b ut the fusion error of the latter was markedly greater than the former. Tumors i n different volume filled by varying concentrations of 18FDG required different pixel deduction proportion. The cylinder volume of PET and CT images were almost the same, so were the images of pulmonary tumor of ten patients. Conclusions T he accuracy of image co-registration of PET-CT on line may fulfill the clinica l demand. Pixel value proportion deduction method can be used for target delineati on on PET image.
Keywords:Tomography  positron-emission  Image processing  compute d-assisted  Target delineations
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