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鼻咽癌调强放疗等效均匀剂量优化方法对腮腺的保护作用
引用本文:乐文友,戴建荣,高黎.鼻咽癌调强放疗等效均匀剂量优化方法对腮腺的保护作用[J].中华放射肿瘤学杂志,2006,15(6):484-488.
作者姓名:乐文友  戴建荣  高黎
作者单位:1. 201206,上海医科达放疗设备有限公司
2. 100021,北京,中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所放疗科
基金项目:首都医学发展科研基金资助项目(2002-3003)
摘    要:目的 探索等效均匀剂量(EUD)优化方法在鼻咽癌调强放疗中对腮腺的保护作用。方法 从已接受调强放疗的鼻咽癌患者中,随机抽取12例。这些患者的治疗计划均是采用物理约束条件优化设计的。以这些计划为基础,将腮腺的物理约束条件改为EUD约束,而保持其他危及器官和靶区的约束条件不变,为每位患者设计一个新的计划,并比较新旧治疗计划。结果 在保证靶区和其他危及器官受照剂量不变情况下,EUD优化能够使腮腺的平均剂量和V30显著降低,经T检验,P值都〈0.05。结论 EUD优化能够降低腮腺的受照剂量,这对降低腮腺放疗并发症具有重要意义,也为靶区加量提供了空间。

关 键 词:鼻咽肿瘤/放射疗法  调强放射疗法  等效均匀剂量  辐射防护  腮腺
收稿时间:2006-04-24
修稿时间:2006年4月24日

Intensity-modulated radiation therapy for nasopharyngeal carcinoma parotid sparing with euivalent uiform dose optimization
YUE Wen-you,DAI Jian-rong,Gao Li.Intensity-modulated radiation therapy for nasopharyngeal carcinoma parotid sparing with euivalent uiform dose optimization[J].Chinese Journal of Radiation Oncology,2006,15(6):484-488.
Authors:YUE Wen-you  DAI Jian-rong  Gao Li
Institution:Department of Radiation Oncology, Cancer Hospital ( Institute
Abstract:Objective The aim of this study was to evaluate the role of an euivalent uiform dose (EUD) based optimization algorithm in sparing the parotids of patients with nasopharyngeal carcinoma (NPC) when they are treated with intensity-modulated radiation therapy(IMRT).Methods 12 patients were randomly selected from the NPC patients who received IMRT treatments.For these patients,the treat- ment plans were designed with physical optimization constraints (dose/dose-volume constraints).Based on these plans,new plans were designed through replacing the physical constraints with maximum EUD for pa- rotids,while keeping the physical objectives for targets and other organs at risk(OARs) unchanged.Com- parison was then made between the new plan,which had EUD constraints to parotids,and the former for each individual patient.Results While maintaining the dose to the targets and the other OARs un- changed,optimization with EUD constraints to parotids decreased the mean dose and V_(30) of parotids signifi- cantly,simultaneously,the dose of target volume and other organs at risk keep stable,the values of probabil- ity were less than 0.05 by T-test.Conclusions The doses to parotids can be reduced through optimization with EUD constraints.This finding is quite helpful to reduce the occurrence rate of parotid complications,and to provide spaces for escalating target dose.
Keywords:Nasopharyngeal neoplasms/radiotherapy  Intensity-modulated radiation therapy  Equivalent uniform dose  Radiation protection  parotid gland
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