中医药一线联合DOX化疗方案对晚期胃癌患者的疗效及预后分析

目的 对中医药一线联合多西他赛+奥沙利铂+卡培他滨(DOX)化疗方案对晚期胃癌患者的疗效及预后情况进行分析,评价该方法对晚期胃癌患者的生存影响.方法 选取216例晚期胃癌患者的临床资料进行回顾性分析,根据治疗方案的不同将其分为试验组和对照组,每组108例.试验组患者采取中医药一线联合DOX化疗方案进行治疗,对照组患者采取单纯DOX化疗方案进行治疗.对两组患者的近期疗效、生活质量、不良反应发生情况以及生存情况进行比较,运用统计学方法进行统计分析.结果 治疗后试验组患者的客观缓解率(ORR)和疾病控制率(DCR)均高于对照组,差异有统计学意义(P﹤0.05);试验组患者的生活质量高于对照组,差异有统计学意义(P﹤0.05);治疗后试验组患者恶心呕吐、腹泻、肝肾功能损伤、白细胞计数减少、血小板计数降低等不良反应的发生率低于对照组,差异有统计学意义(P﹤0.05);试验组患者的中位无进展生存期(PFS)和总生存期(OS)均长于对照组(P﹤0.05).结论 中医药一线联合DOX化疗方案可提高晚期胃癌患者的生活质量,降低化疗产生的不良反应发生率,ORR及生存率均高于单纯DOX化疗方案.

Analysis of the efficacy and prognosis of traditional Chinese medicine combined with first-line DOX chemotherapy regimen for advanced gastric cancer

Objective To analyze the curative effect and prognosis of traditional Chinese medicine combined with first-line Docetaxel+Oxaliplatin+Xeloda(DOX)chemotherapy regimen for advanced gastric cancer,and to evaluate the effect of this regimen on survival of patients. Method The clinical data of 216 patients with advanced gastric cancer were reviewed retrospectively and divided into the experimental group and the control group according to their treatment modes,with 108 patients in each group.The patients in the experimental group were treated with traditional Chinese med-icine combined with first-line DOX chemotherapy regimen,while the patients in the control group were treated only with chemotherapy regimen.The short-term therapeutic efficacy,the quality of life,the incidence of adverse reactions and sur-vival of patients were compared between two groups,and analyzed using statistical methods.Result After treatment,the objective response rate(ORR)and disease control rate(DCR)of patients in experimental group were significantly higher than those in control group;the quality of life of patients in the experimental group was better than that in control group;the incidence of adverse reactions such as nausea and vomiting, diarrhea, liver and kidney dysfunction, leukopenia and thrombocytopenia of patients in experiment group was lower than that of control group;and the median progression-free survival (PFS) and overall survival (OS) of the experimental group were significantly longer than those of the control group;all the differences reached statistical significance(P<0.05).Conclusion In comparison with chemotherapy regi-men alone,traditional Chinese medicine combined with first-line DOX chemotherapy regimen can improve the quality of life, reduce the adverse effects caused by chemotherapy, and improve ORR and survival rate of patients with advanced gastric cancer.