局限期小细胞食管癌2种化疗方案的对比分析

目的：对比分析依托泊苷联合顺铂（EP）与伊立替康联合顺铂（IP）2种化疗方案治疗局限期小细胞食管癌的疗效及预后。方法回顾性分析53例局限期小细胞食管癌患者的临床资料，53例均未出现远处转移，均采用放化疗联合治疗的模式，其中化疗方案的选择为 EP 方案28例，IP 方案25例。采用χ2检验分析2种方案的疾病控制率，Kaplan-Meier 法及 log rank 检验分析其生存时间。结果 EP 组的疾病控制率为78.6%，IP 组的疾病控制率为52.0%，差异有统计学意义（P <0.05）。EP 组中位生存期为9.5个月，IP组为8.0个月，差异有统计学意义（P <0.05）。结论 EP 方案联合放疗治疗局限期小细胞食管癌的近远期疗效均优于 IP 方案联合放疗。

Contrastive Analysis of Two Chemotherapy Regimens in the Treatment of Extensive-stage Small-cell Esophageal Cancer

Objective To contrastively analyze the efficacy and prognosis of two chemotherapy regimens(EP and IP)in the treatment of Limited-stage small-cell esophageal cancer. Methods The data of 53 Patients with Limited-stage small-cell esophageal cancer retrospectively analyzed. All the patients suffered from local advance-ment. They all adopted radiotherapy combined with chemotherapy. The 28 patients of them adopted EP regimen,and the other 25 patients adopted IP regimen. The Chi-square Test was used to analyze the disease control rates of the two kinds of chemotherapy regimens. The Kaplan-Meier and log rank methods were used to estimate the survival time. Results The disease control rate of the EP group was 78. 6% ,and was 52. 0% of the IP group(P < 0. 05).The median survival time of the EP group was 9. 5 months,and was 8. 0 months of the IP group(P < 0. 05). Con-clusion For limited-stage small-cell esophageal cancer,EP regimen combined with radiotherapy is better in the short-term and long-term efficacy than IP regimen combined with radiotherapy.