奥沙利铂加氟脲嘧啶持续静脉滴注治疗晚期鼻咽癌

目的　观察奥沙利铂 (Oxaliplatin ,L_OHP) ,醛氢叶酸 (Leucovorin ,LV) ,氟脲嘧啶 ( 5_Fluorouracil ,5_Fu)持续静脉滴注治疗晚期鼻咽癌 (NPC)的疗效及其不良反应。方法　经病理组织学诊断的鼻咽癌患者 2 1例。L_OHP 13 0mg/m2 静脉滴注 2h ,第 1天 ;LV 2 0 0mg/m2 ,静脉滴注 2h ,随后 5_Fu 3 75mg/m2 ,静脉推注 10min ,再接 5_Fu 3 0g/m2 用输液泵连续滴注 12 0h ,以上治疗 2 1天为 1周期。所有患者至少接受 2个周期治疗。结果　 2 1例均可评价疗效 ,完全缓解 (CR) 3例 ( 14 3 %) ,部分缓解 (PR) 11例 ( 5 2 4%) ,4例患者稳定( 19 0 %) ,主要不良反应为神经毒性 ,骨髓抑制 ,恶心呕吐 ,腹泻 ,黏膜炎等。无治疗相关性死亡者。结论　该研究表明 ,L_OHP加LV和 5_Fu持续滴注治疗晚期鼻咽癌患者 ,缓解率较高 ,毒性相对较低 ,值得进一步临床研究

Oxaliplatin Combined with 5-Fluorouracil Continuous Infusion for Treatment of Advanced Nasopharyngeal Carcinoma

Objective To evaluate the efficacy and toxicity of Oxaliplatin combined with Leucovorin/5_Fluorouracil continuous infusion in the patients with advanced nasopharyngeal carcinoma Methods The patients with a histologic diagnosis of NPC were eligible The chemotherapy regimen was composed of Oxaliplatin 130 mg/m 2 infusion for 2 hours, Leucovorin 200 mg/m 2infusion for 2 hours followed by 10 minute intravenous bolus of 5_Fu 375 mg/m 2,then 120 hours infusion of 5_Fu 3 0/m 2 with an ambulatory pump, repeated every 3 weeks All patients were received at least two cycles of the treatment Results Twenty one patients were enrolled into this study After two cycles of chemotherapy,3 obtained complete remission(CR)(14 3%),11 obtained partial remission (PR)(52 4%),4 had stable disease(SD)(19 0%) The major toxicity included nerve toxicity, myelosuppression, nausea vomiting and mucositis No treatment_related death occurred Conclusion The study indicated that Oxaliplatin combined with Leucovorin/5_Fluorouracil continuous infusion for treatment of advanced NPC had moderate activity and comparatively mild toxicity Further clinical investigation should be warranted