中药R对亚硝基肌氨酸乙酯诱发小鼠前胃癌的预防实验研究

本文应用NSAR诱发NIH小鼠前胃癌的动物模型,研究了中药R阻断癌变的预防作用及其对NK和SOD活性的影响。结果表明,中药R有显著的阻断癌变作用,且呈现明显的剂量效应关系.其中以每公斤体重4g的前期用药组效果较好,其抑制率为77.77％(P<0.01),提示该药主要作用于致癌过程的始发致突变阶段。中药R并可明显地提高NK和SOD活性,具有增强细胞免疫和解毒功能。是一种有苗头的化学预防药物,值得进一步开展人群干予试验和作用机制研究。

Experimental Study on the Traditional Chinese Drug R in the Prevention of NSAR-Induced Cancer of the Proventriculus in Mice

This paper reports the application of NSAR to the induction of squamous cell cancer of the proventriculus for the animal model of the NIH mice and the preventive effect of the traditional Chinese medicine R on blocking canceration as well as on the impact of the activities of the NK and SOD. The results showed that the Chinese drug R had an apparent effect on blocking canceration and demon strated an apparent relationship between dosage and effect. Of the several groups experimented on.ani mals weighing 4g in weight with a period of 42 days of preliminary drug administration showed a relatively good effect with an inhibition rate of 77. 77%(P<0. 01). These findings suggest that the drug play its role chiefly during the initiation stage of carcinogenesis. It can also rise the activities of the NK and SOD and has the function of immunoconsolidation and detoxification,thus constituting a potential chemical for prevention, deserving further studies on its intervention experiments and on the mechanism of its function to be conducted for the humans.