小于30岁低龄肺癌患者的临床分析

背景与目的青年肺癌患者肿瘤恶性程度高,侵袭性强,预后差,已成为多数共识。既往对青年肺癌患者的研究多以40岁或45岁为界,而<30岁的低龄肺癌患者临床资料少见报道。本文回顾分析了解放军总医院从1993年至今17年来诊疗过的<30岁的低龄肺癌患者的病史、分期、治疗及病理特点,为这一年龄段肺癌患者的诊疗提供参考。方法检索解放军总医院收治的1993年以来所有<30岁的肺癌患者,共计53例。其中非小细胞癌患者34例,小细胞癌患者19例。男女比例1.5:1。非小细胞肺癌患者中,腺癌27例,鳞癌6例,腺鳞癌1例,无大细胞癌患者。其中12例接受手术治疗,38例化放疗,3例放弃治疗。结果全组无住院死亡病例,12例手术患者中,手术根治性切除8例,姑息性切除4例。结论低龄肺癌患者腺癌,小细胞癌比例大,多数出现症状就诊时处于晚期,预后差。改善预后应重视常规体检,早期诊断。

Clinical Analysis of Lung Cancer Patients Younger Than 30 Years

Background and objective It is common recognized that young patients of lung cancer have poor prognosis due to relatively higher malignancy and more invasive growth. In the past most studies on young patients of lung cancer selected patients younger than 40 or 45 years old,and there were few clinical materials for younger patients under 30 years. This study retrospectively described the the disease history,stage,treatment and pathology features of lung cancer patients younger than 30 years and aimed to provide references for these patients. Methods Those patients younger than 30 years,once admitted in the General Hospital of the People’s Liberation Army for lung cancer from 1993 to date,were sought in medical record system,and 53 patients were found in total. In this group,there were 34 non-small cell lung cancer(NSCLC) patients and 19 small cell lung cacer(SCLC) patients. The male/female ratio was 1.5:1. In the NSCLC patients,there were 27 adenocarcinomas,6 squamous carcinomas and 1 adenosquamous carcinoma,with no large cell carcinoma involved. In these patients,12 patients received operations while 38 patients got chemo-and/or radiotherapy and 3 quited any treatment. Results There was no death in hospital,however,in the 12 patients who got operation,only 8 patients got complete resection while 4 patients got palliative resection. Conclusion Lung cancer patients younger than 30 years had a high fraction of adenocarcinoma and small cell type pathologically and most of them were in late stage when presenting with symptoms in hospital and would have a dismal prognosis. The routine health examination and early diagnosis should be emphasized to improve the prognosis of these patients.