NKG2D defines tumor-reacting effector CD8+ T cells within tumor microenvironment |
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Authors: | Marija Mojic Kiyomi Shitaoka Chikako Ohshima Sisca Ucche Fulian Lyu Hiroshi Hamana Hideaki Tahara Hiroyuki Kishi Yoshihiro Hayakawa |
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Institution: | 1. Institute of Natural Medicine, University of Toyama, Toyama, Japan;2. Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), Toyama, Japan;3. The, Institute of Medical Science, The University of Tokyo, Tokyo, Japan |
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Abstract: | For successful immunotherapy for cancer, it is important to understand the immunological status of tumor antigen-specific CD8+ T cells in the tumor microenvironment during tumor progression. In this study, we monitored the behavior of B16OVA-Luc cells in mice immunized with a model tumor antigen ovalbumin (OVA). Using bioluminescence imaging, we identified the time series of OVA-specific CD8+ T-cell responses during tumor progression: initial progression, immune control, and the escape phase. As a result of analyzing the status of tumor antigen-specific CD8+ cells in those 3 different phases, we found that the expression of NKG2D defines tumor-reacting effector CD8+ T cells. NKG2D may control the fate and TOX expression of tumor-reacting CD8+ T cells, considering that NKG2D blockade in OVA-vaccinated mice delayed the growth of the B16OVA-Luc2 tumor and increased the presence of tumor-infiltrating OVA-specific CD8+ T cells. |
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Keywords: | cytotoxic T cell immune surveillance NKG2D TOX tumor microenvironment |
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