| 47例术后局部复发非小细胞肺癌三维适形放疗的疗效分析 |
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| 引用本文： | 鲁广,张永伟.47例术后局部复发非小细胞肺癌三维适形放疗的疗效分析[J].中国癌症杂志,2011,21(9). |
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| 作者姓名： | 鲁广 张永伟 |
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| 作者单位： | 浙江萧山医院放疗科,浙江杭州,311201 |
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| 摘 要： | 背景与目的:放射治疗是不可手术非小细胞肺癌(non-small cell lung cancer,NSCLC)重要的局部治疗手段,本研究旨在探讨三维适形放射治疗(three dimensional conformal radiotherapy,3D-CRT)NSCLC术后局部复发患者的不良反应及近远期疗效.方法:回顾性分析我院47例术后局部复发NSCLC患者接受3D-CRT治疗的临床资料.全组放疗剂量中位值60 Gy(46～66 Gy),每次1.8～2.0 Gy,每周5次.36例患者接受了序贯化疗.观察放疗中的不良反应、治疗后的疾病缓解情况,Kaplan-Meier法计算生存率,并进行预后因素分析.结果:84％的患者临床症状有明显缓解.近期疗效:CR 11例,PR 26例,SD 9例,1例进展.随访截至2009年12月31日,死亡42例,存活5例.全组中位生存期15.9个月,其1、2和5年生存率分别为61.7％、36.2％和12.8％.≥2级放射性肺炎7例,其中3级2例.多因素分析发现年龄≤60岁、单纯残端复发以及放疗剂量＞60 Gy是影响生存的独立预后因素.结论:3D-CRT治疗术后局部复发NSCLC安全有效,对经选择的预期生存长的患者应给予积极治疗.
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| 关 键 词： | 非小细胞肺癌 三维适形放疗 局部肿瘤复发 治疗疗效 |
The outcomes of 47 non-small cell lung cancer patients with post-resection recurrent treated with three dimensional conformal radiation therapy |
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| LU Guang,ZHANG Yong-wei.The outcomes of 47 non-small cell lung cancer patients with post-resection recurrent treated with three dimensional conformal radiation therapy[J].China Oncology,2011,21(9). |
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| Authors: | LU Guang ZHANG Yong-wei |
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| Institution: | LU Guang,ZHANG Yong-wei(Department of Radiation Oncology,Zhejiang Xiaoshan Hospital,Hangzhou Zhejiang 311201,China) |
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| Abstract: | Background and purpose:Radiation therapy is an important treatment type for inoperable non-small cell lung cancer(NSCLC).The purpose of this study is to investigate the toxicity and effect on patients with post-resection recurrent cancer treated with three dimensional conformal radiation therapy(3D-CRT).Methods:Forty-seven patients with post-resection recurrent NSCLC treated with 3D-CRT were included in this study.The median radiation dose was 60 Gy(range,46-66 Gy),1.8-2 Gy per fraction,5 fractions per week... |
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| Keywords: | Non-small cell lung cancer 3D-CRT Post-resection recurrent Treatment outcome |
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