| 结直肠癌原发及转移灶中PI3K、p-Akt及mTOR的表达及意义 |
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| 引用本文： | 肖秀英,于宝华,王丽莎,倪淑娟,杨晓燕,朱玉芬.结直肠癌原发及转移灶中PI3K、p-Akt及mTOR的表达及意义[J].中国癌症杂志,2011,21(4). |
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| 作者姓名： | 肖秀英 于宝华 王丽莎 倪淑娟 杨晓燕 朱玉芬 |
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| 作者单位： | 1. 上海市徐汇区中心医院肿瘤科,上海,200031
2. 复旦大学附属肿瘤医院病理科,复旦大学上海医学院肿瘤学系,上海,200032 |
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| 基金项目： | 上海市卫生局青年科研基金，江苏大学临床医学科技发展基金 |
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| 摘 要： | 背景与目的:随着对PI3K/Akt信号通路在结直肠癌发生、发展中研究的不断深入,人们发现该通路在结直肠癌发生、发展及治疗药物开发中有重要价值.本研究旨在探讨PI3K、p-Akt及mTOR在结直肠癌原发灶及转移灶中的表达变化及临床意义.方法:应用免疫组织化学EnVison法检测60例结直肠癌患者原发灶及其转移灶中PI3K、p-Akt及mTOR的表达.结果:PI3K在转移灶中的阳性率显著高于原发灶中的阳性率(46.7% vs 30%,χ2=13.890,P<0.05),mTOR在转移灶中的阳性率显著高于原发灶中的阳性率(55.0% vs 41.7%,χ2=10.823,P<0.05);而p-Akt在原发及转移灶中的表达差异无统计学意义(53.3% vs 50.0%,χ2=0.267,P>0.05).PI3K和mTOR在结直肠癌原发及转移灶中表达均具有相关性,且呈正相关.结论:PI3K和mTOR的表达与结直肠癌转移密切相关,而且转移灶癌细胞PI3K的表达明显增强,mTOR的表达明显下降,可作为临床判断结直肠癌恶性程度、转移及预后的重要参考指标.
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| 关 键 词： | 结直肠癌 免疫组织化学 |
Expression and significance of PI3K, p-Akt and mTOR in colorectal carcinoma and its metastasis spots |
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| XIAO Xiu-ying,YU Bao-hua,WANG Li-sha,NI Shu-juan,YANG Xiao-yan,ZHU Yu-fen.Expression and significance of PI3K, p-Akt and mTOR in colorectal carcinoma and its metastasis spots[J].China Oncology,2011,21(4). |
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| Authors: | XIAO Xiu-ying YU Bao-hua WANG Li-sha NI Shu-juan YANG Xiao-yan ZHU Yu-fen |
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| Institution: | XIAO Xiu-ying,YU Bao-hua,WANG Li-sha,NI Shu-juan,YANG Xiao-yan,ZHU Yu-fen(Department of Oncology,Shanghai Xuhui District Center Hospital,Shanghai 200031,China) |
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| Abstract: | Background and purpose:Developments in the research of PI3K/Akt signaling pathways in colorectal cancer has increased the value of developing and treating colorectal cancer using effective drugs.The aim of this study was to investigate the expression of PI3K,p-Akt and mTOR and their clinical significance in human colorectal carcinoma and metastatic lesions.Methods:Immunohistological staining was used to detect the expression of PI3K,p-Akt and mTOR expressions in 60 cases of colorectal carcinoma as well as t... |
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| Keywords: | PI3K p-Akt mTOR |
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