奥沙利铂抗肿瘤作用及其免疫学新机制的研究进展

奥沙利铂是第3代的铂类抗肿瘤药，具有高效、低毒和不易耐药等特点，明显地不同于第1代和第2代的铂类药物。新近的研究表明，奥沙利铂除了细胞毒作用，即直接作用于肿瘤细胞DNA外，其抗肿瘤作用的重要新机制是影响机体免疫学功能。本文拟对奥沙利铂的抗肿瘤作用的免疫学机制的研究进展进行简要综述和讨论，以帮助肿瘤医师熟悉有关学术动态，拓展临床治疗和研究思路。

Progress in revealing the immunological mechanisms behind the anti-tumor activity of oxaliplatin

Oxaliplatin is the third-generation platinum compound with the some advantages of high efficiency, low toxicity and difficult to resistant etc, thus obviously different from other first-and second-generation platinum drugs. Recent studies have shown that in addition to cytotoxic effect of oxaliplatin that is direct action in cancer cell DNA, immunological mechanism is a new and very impor-tant aspect of its anti-tumour effect. Thus this paper want to briefly review the study progression of immunological mechanisms in oxali-platin anti-tumour effect and its clinical implications,to help oncologists understanding related issues and expanding treatment as well as research thought.