| 放射治疗增敏的研究现状 |
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| 引用本文： | 赵维勇. 放射治疗增敏的研究现状[J]. 临床肿瘤学杂志, 2012, 17(7): 655-659 |
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| 作者姓名： | 赵维勇 |
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| 作者单位： | 1 210029南京医科大学基础医学院2 现工作于南京医科大学第二附属医院放疗科3 210029南京医科大学第一附属医院放疗科 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 在肿瘤治疗中，放射治疗占据着不可替代的重要地位。既往认为由于实体肿瘤中普遍存在乏氧细胞，大多数肿瘤都存在一定的放射抗拒性，故放疗增敏尤其重要。目前，放疗增敏的概念己包括DNA损伤、血管形成、细胞信号转导、细胞周期紊乱、凋亡等多个领域。本文就放射治疗增敏机制及增敏药物的相关研究进展作一综述。
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| 关 键 词： | 肿瘤 放射治疗 放射增敏 化疗药物 靶向药物 |
| 收稿时间： | 2012-02-11 |
| 修稿时间： | 2012-03-25 |
Progression of tumor radiosensitization |
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| ZHAO Wei-yong. Progression of tumor radiosensitization[J]. Chinese Clinical Oncology, 2012, 17(7): 655-659 |
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| Authors: | ZHAO Wei-yong |
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| Affiliation: | 1.School of Basic Medicine， Nanjing Medical University，Nanjing 210029，China |
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| Abstract: | Radiation therapy occupies an irreplaceable position for cancer therapy. Most tumors are radiation resistant with hypoxic cells, so it＇s important to increase the radiosensitization. At present, the radiosensitization concept has developed including DNA damage, angiogenesis, cell signal transduction, cell cycle dysfunction, apoptosis, and other fields. This article reviews the recent literature and the relevant issues concerning the role of the mechanism, strategy, and drugs of radiosensitization. |
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| Keywords: | Tumor Radiotherapy Radiosensitization Chemotheraputic drug Targeted drug |
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