Hepatic resection prolongs overall survival in the selected patients with nasopharyngeal carcinoma liver metastases |
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| Institution: | 1. Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China;2. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China;3. Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China;1. Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People''s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China;2. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, China;3. NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou, 310003, China;4. Institute of Organ Transplantation, Zhejiang University, Hangzhou, 310003, China;1. Department of Surgery, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK;2. Department of Radiology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, UK;3. Leicester Cancer Research Centre, University of Leicester, UK;1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China;2. Department of Pathology, Peking University Third Hospital, Beijing, 100191, China;3. Peking University Health Information Technology Co. Ltd, Beijing, 100080, China;4. Shanghai Songsheng Business Consulting Co. LTD, Beijing, 100000, China;5. Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China;6. Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, China;7. Institute for Artificial Intelligence, Peking University, Beijing, 100091, China;1. Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, 350001, China;2. Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University), China;3. Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), China;4. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China;5. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China;6. School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA;1. Peter MacCallum Cancer Centre, Division of Surgical Oncology, Australia;2. Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia;3. Peter MacCallum Cancer Centre, Department of Molecular Pathology, Australia;4. Peter MacCallum Cancer Centre, Division of Medical Oncology, Australia |
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| Abstract: | BackgroundThe role of surgery in nasopharyngeal carcinoma liver metastases (NCLM) remains elusive, and the current application is limited. We aim to investigate whether hepatic resection (HR) of NCLM improves survival compared with non-hepatic resection (NHR) treatment.MethodsOne hundred and thirty-three patients with NCLM from 2007 to 2017 were divided into two groups. Propensity score matching (PSM) analysis was used to compare the clinical outcomes.ResultsAfter PSM the median overall survival (OS) and the 1, 3 and 5-year OS rates in HR group were 32.60 months, 86.2%, 37.3% and 37.3%, respectively; while for NHR group these values were 19.57 months, 61.5%, 12.9% and 2.9%, respectively (P = 0.008). Multivariate analysis indicated hepatitis B virus infection (P = 0.029) and hepatic resection (P = 0.018) were independent prognostic factors.ConclusionOur study revealed that hepatectomy yields a survival benefit safely compared with systemic treatments, especially for patients with the size of largest metastasis < 5 cm, unilobar distribution of liver tumor and received unanatomical hepatectomy. |
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| Keywords: | Nasopharyngeal cancer liver metastases Hepatic resection Prognosis Propensity score matching study |
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