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Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy
Institution:1. Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China;2. Chongqing Key Laboratory of Immunotherapy, Chongqing, China;3. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA;4. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;5. Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China;6. Research Institute, GloriousMed Clinical Laboratory (Shanghai) Co., Ltd, Shanghai, China;7. School of Life Science, Chongqing University, Chongqing, China;8. School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China;9. TCRCure Biopharma, Durham, NC, USA;10. Department of Radiology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA;11. Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Centre, University of North Carolina, Chapel Hill, NC, USA;12. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA;13. Department of Immunology, Duke University Medical Center, Durham, NC, USA
Abstract:
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Keywords:cancer immunotherapy  immune-oncology  immune checkpoint inhibitors  erythroid progenitors  extramedullary erythropoiesis  myelopoiesis  tumor microenvironment  anti-tumor immunity  immunosuppression  myeloid-derived suppressor cells  MDSCs  transdifferentiation
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