胃癌不同组织学分型与微血管密度及相关因子的关系* |
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引用本文: | 吕靖芳①,孙保存①②③,孙慧誌①,张艳辉③,孙俊英①,赵秀兰①②,古强①②,董学易①②,车娜①②.胃癌不同组织学分型与微血管密度及相关因子的关系*[J].中国肿瘤临床,2015,42(15):737-742. |
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作者姓名: | 吕靖芳① 孙保存①②③ 孙慧誌① 张艳辉③ 孙俊英① 赵秀兰①② 古强①② 董学易①② 车娜①② |
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作者单位: | 作者单位:①天津医科大学病理教研室(天津市300070);②天津医科大学总医院病理科;③天津医科大学附属肿瘤医院病理科 |
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摘 要: | 目的:探讨微血管密度(microvascular density,MVD),基质金属蛋白酶- 2(matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶- 9(matrix metalloproteinase-9,MMP-9)、血管内皮生长因子(vascular endothelial growthfactor,VEGF)、血管内皮生长因子受体1(vascular endothelial growth factor receptor 1,VEGFR1)、血管内皮生长因子受体2(vascularendothelialgrowthfactorreceptor 2,VEGFR2)、p53蛋白与胃癌Lauren 分型及WHO分型的关系。方法:收集89例胃癌患者的临床数据并将其按照Lauren 和WHO标准进行分型。应用单克隆抗体CD34/PAS 双重染色评价89例胃癌组织中的微血管密度,免疫组织化学法检测标本中MMP-2、MMP-9、VEGF、VEGFR1、VEGFR2 和p53蛋白的表达。结果:在胃癌中,MVD与Lauren 分型和WHO分型均无相关性(P > 0.05)。 Lauren 分型与MMP-9、VEGFR1 和p53有相关性(P < 0.05),与MMP-2、VEGF和VEGFR2 无相关性(P > 0.05)。 WHO分型与各肿瘤相关因子均无相关性(P > 0.05)。 Lauren 分型和WHO分型是胃癌患者独立的预后因素(P < 0.05)。 结论:对肿瘤相关因子、血管生成与胃癌发生、发展过程的研究,可能为不同组织学分型的胃癌患者提供新的治疗方法。
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关 键 词: | 胃癌 Lauren 分型 WHO分型 微血管密度 p53? MMP-2? ?MMP-9? ?VEGF? ?VEGFR |
收稿时间: | 2015-04-14 |
Relationship of different histological classifications of gastric cancer with microvessel density and related factors |
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Institution: | 1Department of Pathology, Tianjin Medical University, Tianjin 300070, China; |
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Abstract: | Objective:To investigate the correlations of Lauren classification and world health organization (WHO) classification of gastric cancer (GC) with microvascular density (MVD), matrix metalloproteinase- 2 (MMP- 2), matrix metalloproteinase- 9 (MMP- 9), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor1 (VEGFR 1), vascular endothelial growth factor receptor 2 (VEGFR 2), and p53 . Methods:The clinical data of 89 patients with GC were collected. The collected specimens were categorized on the basis of Lauren classification and WHO classification. CD34 /periodic acid-Schiff (PAS) double staining was performed to validate MVD. Immunohistochemistry was conducted to investigate the expression levels of MMP- 2, MMP-9, VEGF, VEGFR 1, VEGFR 2, and p 53 . Results: MVD was not correlated with Lauren classification or WHO classification (P>0.05 ). Lauren typing was associated with the expression levels of MMP- 9, VEGFR 1, and p 53 (P<0.05 ). WHO classification was not related to any of the factors (P>0.05 ). Cox proportional hazards model revealed that Lauren classification and WHO classification were the prognostic factors of overall survival (P<0.05 ). Conclusion: This research on tumor related factors, angiogenesis, and different classifications of GC may provide new methods to treat this disease. |
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