乏氧诱导因子-1α在非小细胞肺癌中的表达研究 |
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收稿时间: | 29 October 2004 |
修稿时间: | 28 March 2005 |
Expression of Hypoxia Inducible Factor 1α and Its Significance in
Non-small Cell Lung Cancer |
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Authors: | Shu XIA Shiying YU Xianglin YUAN |
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Institution: | (1) Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
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Abstract: | Objective: To explore the expression level and its clinical significance of hypoxia inducible factor
1α (HIF-1α) in non-small lung cancer. Methods: The expression of HIF-1α was detected in 68 human
non-small lung cancer samples by immunohistochemistry. Results: (1) Thirty-nine (57.35%) out of the 68
human non-small lung cancer samples was positive for HIF-1α; (2) The positive rate of HIF-1α in adenocarcinoma
and squamous carcinoma was 54.76% (23/42) and 61.54% (16/26) respectively. No significant
difference was found between adenocarcinoma and squamous carcinoma of non-small lung cancer in the
expression of HIF-1α (P>0.05). The positive rate of HIF-1α in middle-high differentiation was 74.28%
(26/35), significantly higher than in low differentiation (39.39%, 13/33) (P<0.05); (3) The positive expression
of HIF-1α was not correlated to the sexes, ages, tumor stage and lymph node status. Conclusion:
The expression of HIF-1α is higher in non-small lung cancer and is correlated to differentiation. |
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Keywords: | non-small lung cancer hypoxia-inducible factor 1α |
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