Cytologic diagnosis of metastatic melanoma by FNA: A practical review |
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| Authors: | Andrea Ronchi MD Marco Montella MD Federica Zito Marino BD PhD Giuseppe Argenziano MD PhD Elvira Moscarella MD Gabriella Brancaccio MD Giuseppe Ferraro MD Giovanni Francesco Nicoletti MD Teresa Troiani MD Renato Franco MD PhD Immacolata Cozzolino MD PhD |
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| Institution: | 1. Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy;2. Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy;3. Plastic Surgery Unit, Multidisciplinary Department of Medical, Surgical, and Odontological Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy;4. Oncology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy |
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| Abstract: | Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA. |
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| Keywords: | BRAF fine-needle aspiration immunocytochemistry melanoma sentinel node |
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