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丹参对大鼠离体保存再灌注肝脏IL-10 mRNA的影响
引用本文:苏志良,赵浩亮,曹燕,魏爱英.丹参对大鼠离体保存再灌注肝脏IL-10 mRNA的影响[J].中国现代普通外科进展,2013(10):766-768.
作者姓名:苏志良  赵浩亮  曹燕  魏爱英
作者单位:[1]中国人民解放军二六四医院普外科,山西太原030001 [2]山西医科大学第一医院普外科,山西太原030001
摘    要:目的:探讨丹参对大鼠离体保存后再灌注肝脏IL-10 mRNA的影响.方法:建立离体大鼠肝脏保存再灌注模型,.应用RT-PCR方法检测UV液、UV液+丹参保存并再灌注的离体肝脏的IL-10 mRNA表达.结果:丹参保存1 6、24、32 h再灌注的大鼠离体肝脏IL-10 mRNA表达分别为68.55±5.37、49.73±3.74、32.65±2.39;明显高于对照组(37.62±3.3723.70±2.35、1371±1.28),差异有统计学意义(P<0.05).结论:丹参能够增加肝脏保存后再灌注IL-10 mRNA表达,对肝脏保存再灌注损伤可能具有防治作用.

关 键 词:肝移植  再灌注损伤  丹参  白细胞介素-10  大鼠

Effect of salviamiltiorrhiza on expression of IL-10 mRNA in isolated rat liver with preservation and reperfusion
SU Zhi-liang,ZHAO Hao-liang,CAO Yan,WEI Ai-ying.Effect of salviamiltiorrhiza on expression of IL-10 mRNA in isolated rat liver with preservation and reperfusion[J].Chinese Journal of Current Advances in General Surgery,2013(10):766-768.
Authors:SU Zhi-liang  ZHAO Hao-liang  CAO Yan  WEI Ai-ying
Institution:1.Department of Surgery, The 264th Hospital of the PLA,Taiyuan 030001, China; 2.Department of Surgery, The First Affiliated Hospital, SanXi Medical University,Taiyuan 030001, China;)
Abstract:objeetive:To investigate the effect of salviamiltiorrhiza on expression of IL-10 mRNA in isolated rat liver with preservation and reperfusion.Methods:The:model of isolated rat liver with preservation and reperfusion was set up,the expression of IL-10 mRNA was detected with RT-PCR in different preservation time of the isolated liver.Results:ln salv amiltiorrhiza-treated group,expression level of IL-10 mRNA was obviously higher than that in control group after preservation for 16、24、32 h.followed by same reperfusion time (6855 ±5.37 vs 37.62 ±3.37,49.73 ± 3.74 vs 23.70 ± 2.35,32.65 ± 2.39 vs 13.71 ± 1.28,P < 005).Conclusions::Saiviamiltiorrhiza can increase expression of IL-10 mRNA to alleviate reperfusion injure of the isolated rat liver.
Keywords:Liver  Reperfusion injury  Salviamiltiorrhiza  Interieukin-10  Rat
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